HFIR-SNS Advanced Neutron Diffraction and Scattering 2019 Workshop (HANDS2019)

2019年HFIR-SNS高级中子衍射与散射研讨会(HANDS2019)

• 批准号: 1915748
• 负责人: Flora Meilleur
• 金额: $ 1.03万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1915748&HistoricalAwards=false
• 关键词: HFIR; SNS; Advanced; Neutron; Diffraction

This workshop will educate, train and enable a new and diverse generation of researchers for the use of neutrons with state-of-the-art instrumentation and software as applied biological problems. The use of neutrons offers excellent potential to provide previously elusive information about complex biological systems unobtainable with other measurement tools. The workshop is specifically designed for structural biologists and biophysicist. The topics will cover a broad length and time scales relevant to structural biology. One day symposium of talks by leading scientists will be followed by four days of hands on experimentation using neutron beam lines. The organizers will recruit female and members of underrepresented groups to broaden the user base for the use of neutrons in biological research for the future generation of scientists.Recent development of high intensity neutron sources and novel instrumentation will enable to address many of challenges in understanding complex biological systems and to integrate this information with other experimental techniques like cryo-EM, NMR and single molecule fluorescence techniques. A particularly desirable property of neutrons for biology has to do with hydrogen (H), the most abundant element in biological systems. With just one electron, hydrogen is all but invisible to x-rays or light. Neutrons, on the other hand, interact with nuclei, and protons have a relatively strong and negative scattering length. Furthermore, different sensitivity of neutrons to hydrogen and deuterium allows for enhanced visibility of specific parts of complex biological systems through isotopic substitution. This workshop will educate participants in state-of-the-art neutron scattering techniques, instrumentation, data analysis and interpretation while exposing the participants to actual experiments. Techniques included will cover a broad range of time and length scales encountered in structural biology (from atoms to cells) rather than focusing on a single type of experimentation. This workshop is funded by the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences in the Biological Sciences Directorate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该讲习班将教育，培训和使新一代和多样化的研究人员能够使用最先进的仪器和软件使用中子作为应用生物学问题。中子的使用提供了很好的潜力，提供以前难以捉摸的信息，复杂的生物系统无法获得与其他测量工具。该研讨会是专门为结构生物学家和生物化学家设计的。 这些主题将涵盖与结构生物学相关的广泛长度和时间尺度。为期一天的研讨会将由领先的科学家进行会谈，随后将进行为期四天的使用中子束线的实验。 组织者将招募女性和代表性不足的群体成员，以扩大未来一代科学家在生物研究中使用中子的用户群。高强度中子源和新型仪器的最新发展将能够解决理解复杂生物系统的许多挑战，并将这些信息与其他实验技术（如冷冻EM，NMR和单分子荧光技术。中子在生物学上的一个特别理想的性质与氢（H）有关，氢是生物系统中最丰富的元素。只有一个电子的氢，在x射线或光中几乎是不可见的。另一方面，中子与原子核相互作用，质子具有相对较强的负散射长度。 此外，中子对氢和氘的不同灵敏度允许通过同位素替代来增强复杂生物系统的特定部分的可见性。 该讲习班将向参加者介绍最先进的中子散射技术、仪器、数据分析和解释，同时让参加者接触实际实验。 所包含的技术将涵盖结构生物学中遇到的广泛的时间和长度尺度（从原子到细胞），而不是专注于单一类型的实验。该研讨会由生物科学理事会分子和细胞生物科学部的分子生物物理计划资助。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。