CAREER:Shedding New Light on the Miracle of Life

事业：为生命的奇迹带来新的曙光

• 批准号: 1922936
• 负责人: Audrey Bowden
• 金额: $ 9.45万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1922936&HistoricalAwards=false
• 关键词: CAREER; Shedding; New; Light; Miracle

#1351981P.I.: Audrey EllerbeeThe primary research objective of this CAREER Development Proposal (CDP) is to investigate the potential of morphological and biomechanical characteristics to predict viability in the early-stage embryo. This CDP incorporates a well integrated plan for research and education, and biomechanical characteristics to predict viability in the early-stage embryo. The broadly construed aims include: a) hardware development, b) software development, c) scientific experimentation, d) curricular enhancement, e) educational outreach, and f) science policy: This CDP will produce new hardware and software technology to investigate and fundamental questions about changes to the Aphysical properties of the embryo in the moments and hours following fertilization and early development, as well as use that technology to answer some such questions. Together with my collaborators, I will perform the first-in-human studies necessary to validate the relevance and significance of this methodology to address questions regarding fertility that are of broad interest to developmental biologists. In view of recent evidence of the predictive power of imaging-based markers for assessing the viability of embryos, the results of this CDP will likely transform the clinical practice of fertility treatments like in-vitro fertilization.

#1351981 P.I.：Audrey Ellerbee本职业发展建议（CDP）的主要研究目标是研究形态学和生物力学特征预测早期胚胎生存能力的潜力。该CDP结合了一个很好的研究和教育综合计划，以及生物力学特征，以预测早期胚胎的生存能力。广义的目标包括：a）硬件开发，B）软件开发，c）科学实验，d）课程改进，e）教育推广，f）科学政策：该CDP将产生新的硬件和软件技术，以调查有关受精和早期发育后的瞬间和小时内胚胎的非物理特性变化的基本问题，以及使用该技术来回答一些这样的问题。与我的合作者一起，我将进行必要的首次人体研究，以验证这种方法的相关性和重要性，以解决发育生物学家广泛感兴趣的生育问题。鉴于最近的证据表明，基于成像的标记物对评估胚胎存活力的预测能力，该CDP的结果可能会改变体外受精等生育治疗的临床实践。