Collaborative Research: Frameworks: Multiphase Fluid-Structure Interaction Software Infrastructure to Enable Applications in Medicine, Biology, and Engineering

流体与浸没结构物相互作用的物理系统广泛存在于科学和工程的各个领域。这种流体-结构相互作用在生物系统中普遍存在，包括心脏中的血液流动、食物的摄取和肺部的粘液运输。流体-结构相互作用也是新的能源收集方法的一个关键方面，例如从海浪或海浪的运动中提取能量的波能转换器，以及3D打印等先进制造方法。该奖项支持开发先进的计算机模拟基础设施，用于对这一全方位的应用领域进行建模。该项目提出的计算机模型最终可以改进人类疾病的诊断和治疗，优化可再生能源的新方法的设计，并通过改进3D打印的生产时间来降低制造成本。该项目旨在增强IBAMR计算机建模和模拟基础设施，该基础设施提供浸没边界(IB)方法及其扩展的高级实现，并支持自适应网格细化(AMR)。IBAMR用于在分布式存储并行系统上模拟大规模流固耦合模型。目前的IBAMR模型大多假定流体的性质是均匀的，但许多物理系统涉及具有非均匀性质的多相流体模型，如空气-水界面或生物系统的复杂流体环境。该项目旨在通过提高IBAMR处理多相牛顿流动的准确性和效率来扩展IBAMR中最近开发的对多相流处理的支持，并将这种多相流建模能力扩展到处理生物系统中常见的多相复杂(聚合)流体流动，以及处理与燃烧、天体物理和使用立体光固化(3D打印)的添加剂制造模型相关的具有复杂化学反应的流动。该项目还旨在重新设计IBAMR以实现大规模并行，以便它可以有效地使用非常大的计算资源来服务于需要非常高保真的应用程序。该项目还将开发促进使用图像衍生几何的模块，并将开发新的流体-结构耦合方案，以促进独立的流体和固体解算器的使用。这些能力在这个项目中受到心脏、胃肠和肺生理学模型、可再生能源和先进制造的推动。该软件将用于项目组成员开发的课程。该项目还旨在通过增强项目文档和培训材料、主办用户小组会议和提供短期课程来发展IBAMR用户社区。该奖项由NSF高级网络基础设施办公室由土木工程、机械和制造创新司共同资助，旨在提供使能工具来推进潜在的变革性基础研究，特别是在生物力学和机械生物学方面。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Physical systems in which fluid flows interact with immersed structures are found in a wide range of areas of science and engineering. Such fluid-structure interactions are ubiquitous in biological systems, including blood flow in the heart, the ingestion of food, and mucus transport in the lung. Fluid-structure interaction is also a crucial aspect of new approaches to energy harvesting, such as wave-energy converters that extract energy from the motion of sea or ocean waves, and in advanced approaches to manufacturing, such as 3D printing. This award supports the development of an advanced computer simulation infrastructure for modeling this full range of application areas. Computer models advanced by this project could ultimately lead to improved diagnostics and treatments for human disease, optimized designs of novel approaches to renewable energy, and reduced manufacturing costs through improved production times in 3D printing.This project aims to enhance the IBAMR computer modeling and simulation infrastructure that provides advanced implementations of the immersed boundary (IB) method and its extensions with support for adaptive mesh refinement (AMR). IBAMR is designed to simulate large-scale fluid-structure interaction models on distributed memory-parallel systems. Most current IBAMR models assume that the properties of the fluid are uniform, but many physical systems involve multiphase fluid models with inhomogeneous properties, such as air-water interfaces or the complex fluid environments of biological systems. This project aims to extend recently developed support in IBAMR for treating multiphase flows by improving the accuracy and efficiency of IBAMR's treatment of multiphase Newtonian flows, and also by extending this multiphase flow modeling capability to treat multiphase complex (polymeric) fluid flows, which are commonly encountered in biological systems, and to treat reacting flows with complex chemistry, which are relevant to models of combustion, astrophysics, and additive manufacturing using stereolithography (3D printing). This project also aims to re-engineer IBAMR for massive parallelism, so that it may effectively use very large computational resources in service of applications that require very high fidelity. The project will also develop modules that will facilitate the use of image-derived geometries, and it will develop novel fluid-structure coupling schemes that will facilitate the use of independent fluid and solid solvers. These capabilities are motivated within this project by models of cardiac, gastrointestinal, and lung physiology; renewable energy; and advanced manufacturing. This software will be used in courses developed by the members of the project team. The project also aims to grow the community of IBAMR users by enhancing project documentation and training materials, hosting user group meetings, and offering short courses.This award by the NSF Office of Advanced Cyberinfrastructure is co funded by the Division of Civil, Mechanical, and Manufacturing Innovation to provide enabling tools to advance potentially transformative fundamental research, particularly in biomechanics and mechanobiology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.