Secreted fungal proteins in immune evasion and pathogenicity (C06)

分泌的真菌蛋白在免疫逃避和致病性中的作用（C06）

• 批准号: 239827919
• 金额: --
• 依托单位: Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/239827919?language=en
• 关键词: Secreted; fungal; proteins; immune; evasion

C. albicans controls the immune response by secreting immune evasion proteins that contribute to fungal pathogenicity like Pra1. During the first funding period we identified novel mechanisms and/ or mediators of fungal immune escape resulting from inhibiting both innate and adaptive immunity. Further, we have generated monoclonal antibodies (mAbs) against these immune evasion proteins. In the next funding period, we will continue the in vitro studies and extend the analyses to fungal immune escape in mice. Moreover, we will evaluate our anti-fungal mAbs in mouse models of C. albicans infections.

C.白色念珠菌通过分泌免疫逃避蛋白来控制免疫应答，所述免疫逃避蛋白有助于真菌致病性，如Pra 1。在第一个资助期间，我们确定了抑制先天性和适应性免疫导致的真菌免疫逃逸的新机制和/或介质。此外，我们已经产生了针对这些免疫逃避蛋白的单克隆抗体（mAb）。在下一个资助期内，我们将继续进行体外研究，并将分析扩展到小鼠的真菌免疫逃逸。此外，我们将在小鼠C.白色念珠菌感染