Secreted fungal proteins in immune evasion and pathogenicity (C06)

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C. albicans controls the immune response by secreting immune evasion proteins that contribute to fungal pathogenicity like Pra1. During the first funding period we identified novel mechanisms and/ or mediators of fungal immune escape resulting from inhibiting both innate and adaptive immunity. Further, we have generated monoclonal antibodies (mAbs) against these immune evasion proteins. In the next funding period, we will continue the in vitro studies and extend the analyses to fungal immune escape in mice. Moreover, we will evaluate our anti-fungal mAbs in mouse models of C. albicans infections.