Environmentally responsive nanogels for drug delivery (A04)

用于药物输送的环境响应型纳米凝胶 (A04)

• 批准号: 240242064
• 金额: --
• 依托单位: Department of Applied Chemistry and Institute for Polymer Materials (POLYMAT)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240242064?language=en
• 关键词: Environmentally; responsive; nanogels; drug; delivery

This project deals with the development of water-soluble/dispersible stimuli-responsive nanosized soft particles, so-called "nanogels", that should be able to: (i) encapsulate dexamethasone, tacrolimus, tofacitinib, and etanercept; (ii) transport them into the viable skin and/or diffuse into the hair follicles; and (iii) release them in a therapeutically relevant concentration upon an environmental trigger, such as temperature, pH, enzyme activity, or redox potential. Fundamental questions will be addressed regarding the effect of the nanogel properties with respect to drug loading, their dermal delivery capability, mucoadhesive/-penetrating properties, and the mode of action.

该项目涉及开发水溶性/可分散的刺激响应性纳米软颗粒，即所谓的“纳米凝胶”，其应能够：（i）包封地塞米松、他克莫司、托法替尼和依那西普;（ii）将它们运输到有活力的皮肤中和/或扩散到毛囊中;和（iii）在环境触发如温度、pH、酶活性或氧化还原电位时以治疗相关浓度释放它们。基本问题将得到解决的纳米凝胶性质的影响，相对于药物负载，其皮肤递送能力，粘膜粘附/渗透性能，和作用方式。