EPR spectroscopic investigations on drug delivery and release of nanocarriers into excised skin and 3D-skin models (B01)

EPR 光谱研究纳米载体在切除皮肤和 3D 皮肤模型中的药物输送和释放 (B01)

• 批准号: 240243629
• 金额: --
• 依托单位: Institut für Experimentalphysik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240243629?language=en
• 关键词: EPR; spectroscopic; investigations; drug; delivery

The use of EPR is further developed and used in order to localize the drugs and drug analogs within nanocarriers as well as the microenvironment. Drug and carrier are probed simultaneously, so that their structural changes upon application onto skin, 3D-skin models, and mucosa will be studied by continuous wave- and pulsed-EPR methods. Thereby, the release of drugs from nanocarriers and their skin penetration efficiency is investigated and will be extended to the analysis of further drugs, such as etanercept and tofacitinib, within different nanocarriers, such as nanocrystals, pH and redox responsive polymer architectures, depsipeptides, and thermoresponsive nanogels.

EPR的使用被进一步开发和使用，以便将药物和药物类似物定位在纳米载体以及微环境中。同时探测药物和载体，以便通过连续波和脉冲EPR方法研究它们在应用于皮肤、3D皮肤模型和粘膜时的结构变化。因此，研究了药物从纳米载体的释放及其皮肤渗透效率，并将其扩展到分析不同纳米载体（如纳米晶体、pH和氧化还原响应性聚合物结构、缩肽和温度响应性纳米凝胶）内的其他药物（如依那西普和托法替尼）。