Research Initiation Award: The Dynamics of Apoptosis in Leishmania donovani and the Genes Involved
研究启动奖:杜氏利什曼原虫细胞凋亡动力学及相关基因
基本信息
- 批准号:2000095
- 负责人:
- 金额:$ 29.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty member's research capability and effectiveness, improve research and teaching at the home institution, and involves undergraduate students in research experiences. The award to Morehouse College has potential to broaden impacts in several areas. The goal of this project is to study programmed cell death in a model single organism. Comprehension of program cell death in this organism may serve as a model to dissect death pathways in higher organisms. The proposed work will expose underrepresented minority students to cell biology, parasitology, molecular biology and bioinformatics.Currently, we lack knowledge regarding the dedicated molecular pathways that coordinate programmed cellular death (PCD) in single-celled organisms. Of interest is apoptosis, a form of PCD characterized by several conserved features such as cell shrinkage, plasma membrane blebbing, and DNA fragmentation. The occurrence of apoptosis in single-celled organisms remains a debated issue, the resolution of which may have significant implications on our understanding of evolutionary processes. While studies have provided evidence of apoptosis in single-celled organisms, including Leishmania, it remains unclear whether apoptosis in Leishmania shares markers of apoptosis with those found in multicellular organisms, and if so, what mechanisms drive the process. The goal of the proposed study is to characterize apoptosis in Leishmania donovani to advance knowledge towards the identification and evaluation of proteins involved in apoptosis in L. donovani. Specifically, the research aims of this project are to: 1) evaluate the kinetics of apoptosis by examining morphological and biochemical features of apoptosis and 2) analyze gene expression in normal and apoptotic cell populations using RNA-Seq analysis. The proposed project may provide new insight into unicellular apoptosis with potentially novel transcriptional players that are distinct from (or perhaps distantly related to) apoptotic proteins in multicellular organisms. The understanding of apoptosis in Leishmania may also serve as a model to dissect apoptotic pathways and analyze apoptosis in higher eukaryotes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
研究启动奖为历史上黑人学院和大学的初级和中级职业教师提供支持,他们正在建立新的研究项目或重新定向和重建现有的研究项目。预计该奖项将有助于进一步提高教师的研究能力和效率,改善家庭机构的研究和教学,并使本科生参与研究经验。莫尔豪斯学院的获奖有可能扩大在几个领域的影响。本项目的目标是研究单个生物体模型中的程序性细胞死亡。理解这种生物体中的程序性细胞死亡可以作为解剖高等生物体中死亡途径的模型。 拟议的工作将暴露代表性不足的少数民族学生细胞生物学,寄生虫学,分子生物学和生物信息学。目前,我们缺乏知识的专门分子途径,协调程序性细胞死亡(PCD)在单细胞生物体。感兴趣的是细胞凋亡,一种以几种保守特征为特征的PCD形式,如细胞收缩、质膜起泡和DNA片段化。细胞凋亡在单细胞生物体中的发生仍然是一个有争议的问题,其解决可能对我们理解进化过程具有重要意义。虽然研究提供了单细胞生物(包括利什曼原虫)凋亡的证据,但仍不清楚利什曼原虫的凋亡是否与多细胞生物中发现的凋亡标志物相同,如果是这样,是什么机制驱动了这一过程。本研究的目的是描述杜氏利什曼原虫细胞凋亡的特征,以促进对利什曼原虫细胞凋亡相关蛋白的鉴定和评价。donovani。具体而言,本项目的研究目标是:1)通过检查细胞凋亡的形态学和生物化学特征来评估细胞凋亡的动力学,2)使用RNA-Seq分析来分析正常和凋亡细胞群体中的基因表达。拟议的项目可能提供新的见解单细胞凋亡与潜在的新的转录球员是不同的(或可能是远亲)在多细胞生物体中的凋亡蛋白。对利什曼原虫细胞凋亡的理解也可以作为解剖细胞凋亡途径和分析高等真核生物细胞凋亡的模型。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。
项目成果
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