I-Corps: Enhancing bioavailability of bioactive components and nutrients

I-Corps：提高生物活性成分和营养素的生物利用度

• 批准号: 2002839
• 负责人: David McClements
• 金额: $ 5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2002839&HistoricalAwards=false
• 关键词: Corps; Enhancing; bioavailability; bioactive; components

The broader impact/commercial potential of this I-Corps project is to provide a novel approach to improve the stability and bioavailability of beneficial health-promoting ingredients (such as nutraceuticals and vitamins) in the food, supplement, cosmetic, and pet nutrition industries. Manufacturing companies using high-value ingredients are facing the problem of loss of bioactive ingredients during processing. The proposed innovation can reduce the loss by protecting bioactive components from the environmental stresses products experience during processing, transport, and storage, thus increasing economic value, improving food sustainability, and improving efficacy. Furthermore, the technology can also increase the absorption of health-promoting components into the human body, thereby increasing their efficacy. The proposed innovation provides a safe and cost-effective method of improving the bioavailability of bioactive agents through oral administration.This I-Corps project is based on an encapsulation technology utilizing food-grade biopolymers to create cross-linked protective membranes around bioactive-loaded food particles. Advantages include the ability to endure environmental stresses such as extreme pH values, high salt concentrations, freezing and thawing; and improving the bioavailability and absorption of bioactive compounds from food. Food-grade ingredients can be used to assemble colloidal delivery systems to protect bioactives from the harsh conditions foods experience during their shelf life as well as during passage through the gastrointestinal tract. Moreover, they can be used to target bioactive agents to specific tissues. For instance, preliminary studies have shown that the bioaccessibility of curcumin can be increased by 80% using the proposed technology compared with existing products on the market. The proposed technology can therefore increase efficacy, reduce costs, and extend the shelf life of health-promoting functional foods.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力是提供一种新的方法来提高食品、补充剂、化妆品和宠物营养行业中有益健康成分（如营养品和维生素）的稳定性和生物利用度。使用高价值成分的制造公司面临着加工过程中生物活性成分损失的问题。所提出的创新可以通过保护生物活性成分免受产品在加工、运输和储存过程中所经历的环境压力而减少损失，从而增加经济价值，提高食品可持续性并提高功效。此外，该技术还可以增加人体对健康促进成分的吸收，从而提高其功效。该创新项目提供了一种安全且具有成本效益的方法，通过口服提高生物活性剂的生物利用度。该I-Corps项目基于一种封装技术，利用食品级生物聚合物在生物活性食品颗粒周围形成交联保护膜。优点包括能够承受环境压力，如极端pH值，高盐浓度，冷冻和解冻;并提高生物活性化合物的生物利用度和吸收。食品级成分可用于组装胶体递送系统，以保护生物活性物质免受食品在其保质期以及通过胃肠道期间经历的恶劣条件的影响。 此外，它们可用于将生物活性剂靶向特定组织。例如，初步研究表明，与市场上现有的产品相比，使用该技术可以将姜黄素的生物可及性提高80%。该奖项反映了NSF的法定使命，通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。