SBIR Phase I: Formulation parameters for delivery of fatty acids to repel biting insects

这个小型企业创新研究(SBIR)项目的更广泛影响/商业潜力是改进个人使用的驱虫剂，影响莱姆病和寨卡病毒等疾病的传播，并对公众健康产生积极影响。这项拟议的创新将通过使用一种既有效又有吸引力的新化学物质，在护肤品配方中配制一种天然驱虫剂，这种配方是全天然的，直接在皮肤上使用是安全的。这个SBIR第一阶段项目建议使用被归类为化妆品安全的新型天然成分，与标准的合成DEET和目前市场上销售的天然活性物质相比，具有更好的驱虫性，并加入脂肪酸以实现持续的递送机制。该项目将展示一种新的混合解决方案的可行性，展示：1)驱虫效果；2)安全护肤品；3)消费者消费属性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to improve personal-use insect repellents, impacting transmission of diseases such as Lyme and Zika, and positively affecting public health. The proposed innovation will formulate a natural insect repellent within a skincare formulation that is all-natural and safe for use directly on skin, by using a novel chemistry that is both effective and attractive to use. This SBIR Phase I project proposes to use novel, natural ingredients classified as safe for cosmetics and offering superior insect repellency, compared to both the standard synthetic DEET and currently marketed natural actives, incorporating fatty acids for a sustained delivery mechanism. This project will demonstrate feasibility of a new hybrid solution by demonstrating: 1) Efficacy for insect repellency; 2) Safety skin care profile; and 3) Consumer consumption properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.