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MRI: Acquisition of an Operando 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：购买 Operando 500 MHz 核磁共振 (NMR) 波谱仪

基本信息

批准号：
2017891
负责人：
Charles Fry
金额：
$ 48.9万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2017891&HistoricalAwards=false
关键词：
MRI Acquisition Operando 500 MHz

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Wisconsin Madison is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a flow tube accessory and dedicated software that enable online monitoring of chemical reactions in real-time under actual experimental conditions. The instrumentation supports Professor Charles Fry and colleagues at the Wisconsin High-Pressure Reactor (WiHP-NNMR). This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and nearby colleges such as Madison College, University of Wisconsin La Crosse, University of Wisconsin Rock County, University of Wisconsin Whitewater, Lawrence University, Maranatha Baptist University, Indiana State University and Valparaiso University. The Magnetic Resonance Facility plays an important role in strengthening the relationship between the University and Wisconsin citizens by working closely with departmental programs advocating the importance of science, research, and education to the public.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts discovery of metal-metal bonded catalysts and carbon-hydrogen functionalization reactions. The instrumentation is also for exploring photoredox catalysis, polymer mechanochemistry and three-dimensional (3D) printing. In addition, it provides information on operando investigations of transition metal catalyzed reactions. An operando method involves spectroscopic characterization of materials undergoing reaction which is coupled simultaneously with measurement of catalytic activity and selectivity. The spectrometer is also used to develop catalysts for aerobic oxidation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。威斯康星州麦迪逊大学正在购买一台500 MHz核磁共振（NMR）光谱仪，该光谱仪配备了流管附件和专用软件，可在实际实验条件下实时在线监测化学反应。仪器支持查尔斯弗莱教授和同事在威斯康星州高压反应堆（WiHP-NNMR）。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是本机构和附近学院（如麦迪逊学院、威斯康星州拉克罗斯大学、威斯康星州罗克县大学、威斯康星州白水大学、劳伦斯大学、马拉纳瑟浸会大学、印第安纳州州立大学和瓦尔帕莱索大学）化学和生物化学本科生教学、研究和研究培训的组成部分。磁共振设备在加强大学和威斯康星州公民之间的关系中发挥着重要作用，通过与部门计划密切合作，倡导科学，研究和教育的重要性。核磁共振光谱仪的奖项旨在加强各级研究和教育。它特别影响金属-金属键合催化剂和碳氢官能化反应的发现。该仪器还用于探索光氧化还原催化，聚合物机械化学和三维（3D）打印。此外，它还提供了过渡金属催化反应的操作研究信息。一种操作方法涉及进行反应的材料的光谱表征，其与催化活性和选择性的测量同时耦合。该光谱仪还用于开发有氧氧化催化剂。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。