Organic Synthesis of Potent and Selective Indol-3-yl-oxoacetamides for PET Imaging of Cannabinoid Receptor Type 2

用于 2 型大麻素受体 PET 成像的有效选择性吲哚-3-基-氧代乙酰胺的有机合成

• 批准号: 242495620
• 负责人: Dr. Rares-Petru Moldovan
• 金额: --
• 依托单位: Forschungsstelle Leipzig - Interdisziplinäre Isotopenforschung -
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/242495620?language=en
• 关键词: Organic; Synthesis; Potent; Selective; Indol

Two types of proteins activated by cannabinoids (named Cannabinoid Receptors or CB) have been cloned so far. In the intended project, the development of a fluorinated, highly selective ligand for the CB type 2 is planned. Several derivatives of the lead molecule will be designed and the best one will be used for radiofluorination and further investigation with Positron-Emision-Tomography (PET). The development of such a radio-tracer will enable a better understanding of the cannabinoid system and the early stage diagnosis of neurodegenerative diseases (ex. Alzheimer, Parkinson) and cancer.

到目前为止，已经克隆了两种由大麻素激活的蛋白质（称为大麻素受体或CB）。在计划的项目中，计划开发用于CB 2型的氟化高选择性配体。将设计几种铅分子的衍生物，最好的一种将用于放射性核素显像和正电子散射断层扫描（PET）的进一步研究。这种放射性示踪剂的开发将使人们能够更好地了解大麻素系统和神经退行性疾病的早期诊断。阿尔茨海默氏症，帕金森）和癌症。