Impact of the nicotinergic alpha7 receptor on cortical plasticity in smokers and nonsmokers

烟碱能 α7 受体对吸烟者和非吸烟者皮质可塑性的影响

• 批准号: 24408615
• 负责人: Professor Dr. Michael A. Nitsche
• 金额: --
• 依托单位: Klinik für Klinische Neurophysiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/24408615?language=en
• 关键词: Impact; nicotinergic; alpha7; receptor; cortical

Nicotine is a strong inductor and modulator of cortical activity and long-term potentiation. Hereby it influences learning and memory processes as well as addiction. Nicotine-dependent cognitive improvements in humans seem to differ between smoking and not smoking individuals, as presumed by the deficit compensating hypothesis of nicotine consumption. This project pursues the following aims: (i) First we will differentiate acute cortical excitability shifts elicited by nicotine in smokers and non-smokers (Collaboration with Prof. Wodarz). (ii) We will induce LTPand LTD-like cortical neuroplasticity changes by transcranial direct current stimulation with and without nicotine in smokers and non-smokers, (iii) We will correlate nicotineenhanced neuroplasticity with cognitive performance and performance-related cerebral activity, as revealed by fMRI, in smokers and non-smokers, (iv) The interdependence of neurophysiological and cognitive effects with genetically defined phenotypes (collaboration with Proff. Winterer, Batra, Andreas) of smokers will be explored. In summary, we aim to develop a neurophysiology-based in vivo model of the impact of nicotine on cerebral function, which will help to understand the mechanisms of nicotine addiction and relapse after withdrawal to a greater extent.

尼古丁是皮层活动和长时程增强的强诱导剂和调节剂。因此，它影响学习和记忆过程以及成瘾。尼古丁依赖的认知改善在吸烟和不吸烟的人之间似乎是不同的，正如尼古丁消耗的赤字补偿假说所假设的那样。该项目追求以下目标：（i）首先，我们将区分吸烟者和非吸烟者中尼古丁引起的急性皮质兴奋性变化（与Wodarz教授合作）。(ii)我们将通过在吸烟者和非吸烟者中使用和不使用尼古丁的经颅直流电刺激来诱导LTP和LTD样皮质神经可塑性变化，（iii）我们将在吸烟者和非吸烟者中将尼古丁增强的神经可塑性与认知性能和性能相关的大脑活动相关联，如fMRI所揭示的，（iv）神经生理学和认知效应与遗传定义的表型的相互依赖性（与Proff合作）。Winterr，Batra，Andreas）的吸烟者将被探索。总之，我们的目标是建立一个基于神经生理学的尼古丁对大脑功能影响的体内模型，这将有助于更大程度地了解尼古丁成瘾和戒断后复发的机制。