Regulation of the actin cytoskeleton by LIM kinase 2

LIM 激酶 2 对肌动蛋白细胞骨架的调节

• 批准号: DP0879816
• 负责人: Dr Ora Bernard
• 金额: $ 13.54万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879816
• 关键词: Regulation; actin; cytoskeleton; LIM; kinase

Because the regulation of actin cytoskeleton is essential for many cellular processes including cell motility and the normal function of neurons, it is of great importance to understand its regulation. Elucidation of the molecular and biological mechanisms underlying the actin cytoskeleton including cell motility may enable the identification of novel therapeutic targets for the treatment of diseases such as cancer metastasis, Alzheimer disease (AD) and/or Multiple Sclerosis (MS) in which the regulation of the actin cytoskeleton is affected.

由于肌动蛋白细胞骨架的调节对于包括细胞运动和神经元正常功能在内的许多细胞过程是必不可少的，因此了解其调节具有重要意义。阐明肌动蛋白细胞骨架（包括细胞运动性）的分子和生物学机制可以鉴定新的治疗靶标，用于治疗其中肌动蛋白细胞骨架的调节受到影响的疾病，例如癌症转移、阿尔茨海默病（AD）和/或多发性硬化症（MS）。