FOR 2149: Elucidation of Adhesion-GPCR Signalling

粘附型G蛋白偶联受体是一大类七跨膜（7 TM）受体。7 TM受体已被证明是无数生理功能的关键，是现代药物干预的保证。粘附-GPCR似乎与7 TM受体超家族的其余部分形成鲜明对比，因为它们是迄今为止了解最少的7 TM受体类别。研究单位的科学目标集中在粘附GPCR生物学的几个基本方面，涉及其信号传导的生理和药理学特征，包括其机械传感器的作用，作为其激活后的信号传导步骤的栓系作用的存在，通过粘附GPCR控制的非典型信号的分析及其对细胞骨架动力学的影响。此外，研究单位致力于解构粘附GPCR对肿瘤和炎症发生的影响。这些问题是从不同的方法论角度，包括生理学，生物化学，结构和细胞生物学，药理学，光遗传学和纳米成像技术的目标。重要的是，无脊椎动物和脊椎动物模型的优势将被用于协同努力，将粘附-GPCR信号传导中的分子步骤与这些异常受体控制的生理过程联系起来。特别注意的是，不仅在方法学上，而且特别是在概念层面上，以促进提取粘附-GPCR信号传导的一般原则。

Adhesion-type G protein-coupled receptors form a large class ofseven-transmembrane spanning (7TM) receptors. 7TM receptorshave proven the linchpin for countless physiological functions and atreasure trove for modern pharmaceutical intervention. Adhesion-GPCR appear in stark contrast to the rest of the 7TM receptorsuperfamily as they are by far the most poorly understood 7TMreceptor class. The scientific aims of the Research Unit focus onseveral fundamental aspects of adhesion GPCR biology pertaining tothe physiological and pharmacological features of their signaling.These include their role of mechanosensors, the presence of tetheredagonism as the signal transducing step upon their activation, theanalysis of non-canonical signals controlled through adhesion GPCRsand their effect on cytoskeletal dynamics. In addition, the ResearchUnit strives to deconstruct the impact of adhesion GPCRs on theemergence of neoplasias and inflammation. These questions aretargeted from different methodological angles encompassingphysiology, biochemistry, structural and cell biology, pharmacology,optogenetics and nanoscopic imaging techniques. Importantly, thestrengths of invertebrate and vertebrate models will be used tosynergise efforts in linking molecular steps in adhesion-GPCRsignalling to physiological processes governed by these unusualreceptors. Specific care is dedicated to interlock the projects not onlymethodologically, but especially at the conceptual level to facilitate theextraction of general principles of adhesion-GPCR signalling.