NSF Postdoctoral Fellowship in Biology FY 2021: Effects of individual experience on population social structure: integrating development, gene expression and social ecology

2021 财年 NSF 生物学博士后奖学金：个人经历对人口社会结构的影响：整合发展、基因表达和社会生态

• 批准号: 2109636
• 负责人: Matthew Zipple
• 金额: $ 13.8万
• 依托单位: Zipple, Matthew
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109636&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2021, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. All societies are made up of individuals and their complex set of characteristics and interactions. At the same time, individuals’ health and behavior in adulthood are shaped by the social and physical experiences of early life. Yet, it remains unclear how these early life experiences shape higher level social structure. The fellow will use semi-natural populations of mice to fill this gap by studying how variation in individuals’ previous experiences and resulting behavior in adulthood collectively shape the structure of the larger society in which they live. In addition to the research outcomes from this work, the fellow will continue to develop two projects that improve and expand the dissemination of research in the areas of animal behavior, life history, and evolution. The first project is the Long-Term Animal Research seminar series, an innovative virtual seminar series with a global audience (10000 views on YouTube in the last 12 months). The second project is the Animal Behavior Podcast, which the fellow is currently developing with the support of the Animal Behavior Society (coming June 21, 2021). Each episode features conversations with leading researchers in the field of animal behavior, combining discussions of research with professional development, personal experiences, and history of the field.The fellow will leverage a populations of semi-wild mice to understand the links between individuals’ experience and phenotype, how that phenotype shapes social structure, and ultimately how society influences the individual. First, the fellow will measure the impacts of early life social isolation on individuals’ growth, social behavior, and transcriptome. Second, the fellow will generate populations of semi-wild mice, made up of individuals that experienced social isolation or social connection in early life. The fellow will then use social network analyses to understand the ways in which population-level social structures differ, depending on the early experiences of individuals in the population. Finally, the fellow will use molecular approaches to understand the extent to which the epigenetic consequences of early social experience are transmitted across generations. This research will provide insight into the complex relationships between individual experience, phenotype, and larger social structures in a single study system.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动资助了2021财年的NSF生物学博士后研究奖学金，即调查基因组，环境和表型之间相互作用的生命规则的综合研究。该研究金支持研究员的研究和培训，以创新的方式为生活规则领域做出贡献。所有社会都是由个人及其复杂的特征和相互作用组成的。与此同时，个人的健康和成年行为是由早期生活的社会和身体经历塑造的。然而，这些早期的生活经历如何塑造更高层次的社会结构仍不清楚。该研究员将使用半自然的小鼠种群来填补这一空白，研究个体先前经历的变化以及成年后的行为如何共同塑造他们所生活的更大社会的结构。除了这项工作的研究成果外，该研究员还将继续开发两个项目，以改善和扩大动物行为，生活史和进化领域的研究传播。第一个项目是长期动物研究研讨会系列，这是一个创新的虚拟研讨会系列，拥有全球观众（过去12个月在YouTube上有10000次观看）。第二个项目是动物行为播客，该研究员目前正在动物行为学会的支持下开发（即将于2021年6月21日）。每一集都有与动物行为领域的顶尖研究人员的对话，将研究与专业发展、个人经历和该领域的历史相结合。研究员将利用一群半野生小鼠来了解个体的经验和表型之间的联系，表型如何塑造社会结构，以及最终社会如何影响个体。首先，该研究员将测量早期社会隔离对个人成长，社会行为和转录组的影响。第二，研究人员将产生半野生小鼠种群，由在早期生活中经历过社会孤立或社会联系的个体组成。然后，研究员将使用社会网络分析来了解人口水平的社会结构的不同方式，这取决于人口中个体的早期经历。最后，该研究员将使用分子方法来了解早期社会经验的表观遗传后果在多大程度上代代相传。这项研究将在一个单一的研究系统中提供对个体经验、表型和更大的社会结构之间复杂关系的洞察。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。