NSF Postdoctoral Fellowship in Biology FY 2021: Uncovering the Genomic Basis of Adaptation in Quercus alba, a Model for Forest Trees

2021 财年 NSF 生物学博士后奖学金：揭示白栎（林木模型）适应的基因组基础

• 批准号: 2109716
• 负责人: Drew Larson
• 金额: $ 21.6万
• 依托单位: Larson, Drew A
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109716&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This action funds an NSF Plant Genome Postdoctoral Research Fellowship in Biology for FY 2021. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Drew A. Larson is “Uncovering the genomic basis of adaptation in Quercus alba, a model for forest trees”. The host institutions for the fellowship are Indiana University, the Morton Arboretum, and the University of Kentucky, and the sponsoring scientists are Dr. Matthew W. Hahn, Dr. Andrew L. Hipp, and Dr. C. Dana Nelson. Forest trees are valuable crop species and are central to the functioning of many natural and managed ecosystems. Oaks in particular are some of the most abundant and ecologically important trees in North America. They provide food and habitat for wildlife and raw materials for a variety of construction and cooperage industries. Understanding how populations of oak trees adapt at local and regional scales will provide insight into how these and other species will be affected by climate change and pest pressure in the coming decades. Oak species are known to produce hybrids with one another, allowing genes to move among species. However, much less is known about how this sharing of genes impacts how oak populations adapt to their local environments. This research will address how adaptation and hybridization interact to affect the genomes of oaks in the Eastern United States. It will also shed light on the evolution of genes that provide resistance to disease, which may prove useful for genetic improvement efforts in these economically valuable species. The Fellow will mentor undergraduates in research projects related to the scientific goals of the project. He will also develop an annual series of outreach events in collaboration with the Morton Arboretum in which participants will learn about trees (and other plants), genomics, and how to pursue a career in STEM.Population genomic and comparative genomic methods will be used to uncover the adaptive forces that shape the genomes of oaks (Quercus spp.), and the white oak (Quercus alba) in particular. The genomic regions and functional classes of genes involved in local and regional adaptation to climate in Q. alba populations will be investigated, with the goal of developing a fundamental understanding of the genomic basis of adaptation in Q. alba. Sampling of natural populations to be sequenced will be focused at the northern and southern extremes of the current range of Q. alba, in order to provide the greatest contrast between environments and to maximize power to detect adaptive differences. The project will investigate genomic introgression into Q. alba across its range and examine whether congeneric species have contributed alleles of adaptive significance. The project will also investigate the evolution of disease resistance genes across Quercus in a phylogenetic context. Data generated during the project will be highly reusable and extendable for future research and will be available online to facilitate its continued use by the scientific community. Research outcomes will be shared broadly, both at academic conferences and public-facing seminars throughout the Fellowship. Keywords: comparative genomics, forest trees, gene family evolution, plant genomes, population genomics, natural selection, R genes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动为2021财年的NSF植物基因组博士后生物学研究奖学金提供资金。该研究金支持研究员在东道实验室的研究和培训计划，研究员还提出了扩大生物学参与的计划。该奖学金的研究和培训计划的标题是Drew A. Larson的论文是“Uncovering the genomic basis of adaptation in Quercus alba，a model for forest trees”。该奖学金的主办机构是印第安纳州大学、莫顿植物园和肯塔基州大学，赞助科学家是马修·W。作者：Andrew L.希普和C博士丹娜纳尔逊。森林树木是宝贵的作物物种，是许多自然生态系统和管理生态系统运作的核心。特别是橡树是北美最丰富和生态重要的树木之一。它们为野生动物提供食物和栖息地，为各种建筑和制桶业提供原材料。了解橡树种群如何在当地和区域范围内适应，将有助于深入了解这些物种和其他物种在未来几十年将如何受到气候变化和害虫压力的影响。众所周知，橡树物种之间会产生杂交种，从而使基因在物种之间转移。然而，人们对这种基因共享如何影响橡树种群如何适应当地环境知之甚少。这项研究将解决如何适应和杂交相互作用，影响基因组的橡树在美国东部。它还将揭示提供抗病性的基因的进化，这可能对这些具有经济价值的物种的遗传改良工作有用。研究员将指导本科生进行与项目科学目标相关的研究项目。他还将与莫顿植物园合作开发一系列年度推广活动，参与者将学习树木（和其他植物），基因组学以及如何从事STEM事业。人口基因组学和比较基因组学方法将用于揭示塑造橡树基因组的适应力（栎属），尤其是白色橡树。研究了参与局部和区域气候适应的Q. alba种群将进行调查，发展的目标是在Q适应基因组基础的基本理解。阿尔巴。待测序的自然种群的采样将集中在目前Q范围的北方和南方极端。ALBA，以便提供环境之间的最大对比度并最大化检测自适应差异的能力。本项目将研究基因组渗入Q。alba在其范围内，并检查是否同源物种贡献了适应意义的等位基因。该项目还将调查栎属抗病基因在系统发育背景下的进化。该项目期间产生的数据将高度可重复使用和扩展，以供未来研究使用，并将在网上提供，以方便科学界继续使用。研究成果将在整个奖学金期间的学术会议和面向公众的研讨会上广泛分享。保留字：该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。