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NSF Postdoctoral Fellowship in Biology FY 2021: The role of vegetative development on plant response to environmental stress from genomic and physiological perspectives

2021 财年 NSF 生物学博士后奖学金：从基因组和生理学角度看营养发育对植物对环境胁迫反应的作用

基本信息

批准号：
2109780
负责人：
Erica Lawrence-Paul
金额：
$ 21.6万
依托单位：
Lawrence Erica H
依托单位国家：
美国
项目类别：
Fellowship Award
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2109780&HistoricalAwards=false
关键词：
NSF Postdoctoral Fellowship Biology FY

项目摘要

This action funds an NSF Plant Genome Postdoctoral Research Fellowship in Biology for FY 2021. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Dr. Erica H Lawrence is "The role of vegetative development on plant response to environmental stress from genomic and physiological perspectives" The host institution for the fellowship is the Pennsylvania State University and the sponsoring scientist is Dr. Jesse R Lasky.Plant form and function is altered as plants transition through different developmental phases. The changes in morphology and physiology that accompany developmental phase transitions influence plant environmental response and performance. While the impact of the vegetative-to-reproductive transition has garnered most of the attention of biologists, there is still much to learn about the more visually subtle transition between juvenile and adult vegetative phases, known as vegetative phase change. This project investigates how vegetative phase change alters plant tolerance of environmental stressors in the important crop species sorghum (Sorghum bicolor (L) Moench), and how variation in the timing of this transition may benefit plants in their native climates. This examination of developmental effects on plant performance will generate new resources to enhance crop breeding, restoration and conservation efforts. The research funded here will provide training in developmental biology, genomics, evolutionary and ecological genetics, RNA sequencing and gene expression. Broader impacts include broadening participation of historically excluded groups in STEM fields through partnerships with established programs serving the Philadelphia and Centre county, PA communities, the development of K12 curriculum related to plant biology, and training opportunities for undergraduates.To understand what role vegetative phase change has on plant performance, we must gain a better understanding of the natural variation, adaptive selection and altered physiology associated with it. Using the genetically diverse and stress tolerant crop species sorghum (Sorghum bicolor (L) Moench), the project will identify 1) The natural variation surrounding the timing of vegetative phase change among genotypes locally adapted to diverse climates, genetic regulators of this variation, and evidence of environmental selection on these regulators, and 2) Transcriptomic and physiological differences of drought response between juvenile and adult vegetative phases. To do so, variation in the timing of vegetative phase change will be scored across a diverse mapping panel. This data set will be used to identify the genetic regulators of natural variation and to investigate associations between the timing of vegetative phase change and important plant performance traits. Approaches in population and quantitative genetic statistics will be used to test for evidence that these regulators are under selection and play a role in local adaptation. In the field, genotypes will be subjected to drought stress during either juvenile or adult phases to discern transcriptomic and physiological variation in drought stress response between these phases. Further, an understanding of how the timing of drought exposure and vegetative phase change interact to effect whole plant performance will be gained. Together these aims will provide a depiction of how vegetative phase change may contribute to adaptation and future breeding efforts for both natural and agricultural ecosystems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一行动为2021财年NSF植物基因组生物学博士后研究奖学金提供了资金。该奖学金支持在东道主实验室为该研究员制定的研究和培训计划，该研究员还提出了扩大生物学参与度的计划。Erica H Lawrence博士这项奖学金的研究和培训计划的标题是：从基因组和生理角度看营养发育对植物对环境压力的反应的作用。该奖学金的主办机构是宾夕法尼亚州立大学，赞助科学家是Jesse R Lask.博士。植物的形态和功能随着植物在不同发育阶段的转变而改变。伴随着发育阶段转变的形态和生理变化会影响植物对环境的反应和表现。虽然营养到生殖转变的影响已经引起了生物学家的大部分关注，但关于幼年和成年营养阶段之间视觉上更微妙的转变，也就是所谓的营养阶段变化，仍然有很多需要研究的地方。本项目研究了营养相变化如何改变重要作物高粱对环境胁迫的耐受性，以及这种转变时机的变化如何使植物在其原生气候中受益。这种对植物表现的发育影响的研究将产生新的资源，以加强作物育种、恢复和保护工作。这里资助的研究将提供发育生物学、基因组学、进化和生态遗传学、RNA测序和基因表达方面的培训。更广泛的影响包括通过与费城和中心县、宾夕法尼亚州社区建立的项目合作，扩大历史上被排除在外的群体在STEM领域的参与，开发与植物生物学相关的K12课程，以及为本科生提供培训机会。为了了解营养阶段变化对植物表现的作用，我们必须更好地了解与之相关的自然变异、适应性选择和改变的生理学。利用遗传多样性和耐胁迫的作物品种高粱(高粱)，该项目将确定1)当地适应不同气候的不同基因型之间围绕营养阶段变化时间的自然变异，这种变异的遗传调控因素，以及这些调控因素的环境选择的证据，以及2)幼年和成年营养阶段干旱反应的转录和生理差异。要做到这一点，营养阶段变化的时间变化将在一个不同的测绘小组中进行评分。这个数据集将被用来识别自然变异的遗传调节因素，并调查营养阶段变化的时间与重要植物表现性状之间的关系。将使用种群和定量遗传统计的方法来测试这些调节器正在被挑选并在当地适应中发挥作用的证据。在田间试验中，不同的品种在幼期或成熟期都会受到干旱胁迫，以区分不同时期干旱胁迫反应的转录和生理变化。此外，还将了解干旱暴露的时间和营养阶段变化如何相互作用，以影响整个植物的表现。这些目标将共同描述营养阶段的变化如何有助于自然和农业生态系统的适应和未来的育种工作。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。