MRI: Acquisition of Photothermal Infrared Raman Microscope for High Resolution Label-free Chemical Imaging

该奖项由主要研究仪器和化学研究仪器项目联合支持。俄亥俄州立大学正在购买一台光热红外-拉曼显微镜傅立叶变换红外（FTIR）成像显微镜，以支持Zachary Schultz及其同事Susan Olesik， Luis Rodriguez-Saona， Vicky Doan-Nguyen和Barbara Dunlap的研究。该仪器促进了生物化学和细胞过程，电化学，催化和分析化学领域的研究。一般来说，红外光谱和拉曼光谱分别测量与样品相互作用时吸收和散射辐射的强度。当辐射与化合物相互作用时，分子可以开始以一定的频率振动或旋转。在异质样品中，这个强大的分析工具有助于定性地识别化学成分。所述信息还可用于创建样品中所述材料组成的图像。该仪器提高了许多院系各级学生的教育、研究和教学努力，并为附近的机构提供了可访问性。该奖项旨在获得光热红外拉曼显微镜，旨在加强各级，特别是化学和生物化学方面的研究和教育。研究重点是亚细胞微环境的化学成像，如细胞模型中的药物靶向和番茄红素代谢，以及将红外成像用于能量存储应用的研究，如用于Li-S电池电化学增强的多功能阴极和跟踪聚硫抑制。其他涉及表征聚合物纳米颗粒复合材料和高通量诊断筛选的应用也在进行中。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The Ohio State University is acquiring a photothermal Infrared-Raman microscope Fourier Transform Infrared (FTIR) imaging microscope to support the research of Zachary Schultz and colleagues Susan Olesik, Luis Rodriguez-Saona, Vicky Doan-Nguyen and Barbara Dunlap. This instrument facilitates research in the areas of biochemistry and cellular processes, electrochemistry, catalysis, and analytical chemistry. In general, the infrared and Raman spectroscopies measure the intensity of the absorbed and scattered radiation when it interacts with a sample, respectively. When radiation interacts with a compound, the molecules can begin to vibrate or rotate at certain frequencies. In a heterogeneous sample, this powerful analytical tool helps identify chemical composition qualitatively. The information can also be used to create an image of the material composition in a sample. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments as well as provides accessibility for use at nearby institutions. This award to acquire a photothermal infrared-Raman microscope is aimed at enhancing research and education at all levels, especially in chemistry and biochemistry. Studies focused on chemically imaging sub-cellular microenvironments such as drug targeting and lycopene metabolim in cellular models are pursued as are those focused on using IR photoimaging for energy storage applications such as multi-functional cathodes for electrochemical enhancement in Li-S batteries and tracking polysulfude suppresion. Other applications involving characterizing polymer nanoparticle composites and high throughput diagnostic screening are also being pursued.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.