SBIR Phase I: A Novel Respiratory Bag-Valve-Mask Resuscitator

SBIR 第一阶段：新型呼吸袋-瓣膜-面罩复苏器

• 批准号: 2124771
• 负责人: Adam Scott
• 金额: $ 25.59万
• 依托单位: COMPACT MEDICAL SOLUTIONS LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2124771&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Respiratory; Bag

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of a novel resuscitator to ventilate patients with respiratory failure or cardiac arrest. With almost 300,000 cases of out-of-hospital cardiac arrest and approximately 350,000 in-hospital cases each year in the United States, a modest increase of just 5% in the number of patients surviving cardiac arrest would correspond to more than 33,000 additional lives saved. In 2017, the combined direct and indirect costs of deaths from out-of-hospital cardiac arrest for patients under 50 years of age to be $455 billion, with an estimate of $1.8 trillion for all deaths from cardiac arrest. On this basis, every 1% increase in the out-of-hospital cardiac arrest survival rate would result in a $4.5 billion cost saving to the United States economy.The proposed project addresses the technical challenges associated with a novel device.This Small Business Innovation Research (SBIR) Phase I project advance translation of a bag-valve-mask resuscitator that restricts the volume, pressure, and rate of ventilation to safe levels for any patient, from infant to adult. The goal of the project is to design and test a fully functioning prototype that incorporates an easy-to-use mechanism for quickly and simultaneously adjusting both the maximum volume of air delivered and the maximum pressure, and a mechanism for restricting ventilation rate. The project objectives are: (1) prototype and test a novel dial-operated mechanism for simultaneous volume and pressure control; (2) test a flow-based mechanism for restricting the ventilation rate; (3) compare the prototype performance with that of a standard bag-valve-mask resuscitator used by a group of trained medical personnel. Successful completion of this project will result in a fully functional prototype, a valuable set of data on the device performance, and important feedback from end-users on design, ease of use, and device functionality to inform future modifications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

小型企业创新研究(SBIR)第一阶段项目的更广泛影响/商业潜力是开发一种新型复苏器，为呼吸衰竭或心脏骤停患者进行呼吸机治疗。在美国，每年有近30万例院外心脏骤停和约35万例院内心脏骤停，心脏骤停患者存活人数仅略有增加5%，就相当于额外挽救了3.3万多人的生命。2017年，50岁以下患者院外心脏骤停死亡的直接和间接成本合计为4550亿美元，所有心脏骤停死亡估计为1.8万亿美元。在此基础上，院外心脏骤停存活率每增加1%，将为美国经济节省45亿美元的成本。拟议的项目解决了与新设备相关的技术挑战。这个小型企业创新研究(SBIR)第一阶段项目提前翻译了一种袋式阀门面罩复苏器，它将容量、压力和通气率限制在从婴儿到成人的任何患者的安全水平。该项目的目标是设计和测试一个功能齐全的原型，该原型包含一个易于使用的机制，可以快速同时调整最大风量和最大压力，以及一个限制通风率的机制。该项目的目标是：(1)设计并测试一种可同时控制流量和压力的新型转盘操作机构；(2)测试一种基于流量的限制通气率的机构；(3)将样机的性能与一组训练有素的医务人员使用的标准袋式阀门面罩复苏器进行比较。该项目的成功完成将产生一个功能齐全的原型，一组关于设备性能的宝贵数据，以及来自最终用户的关于设计、易用性和设备功能的重要反馈，以便为未来的修改提供信息。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。