STTR Phase I: A mesh-free, sling-free, minimally invasive treatment for stress urinary incontinence in women

STTR 第一期：无网、无吊带的微创治疗女性压力性尿失禁

• 批准号: 2127552
• 负责人: Ghazaleh Rostami Nia
• 金额: $ 25.6万
• 依托单位: ALTYX SURGICAL, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2127552&HistoricalAwards=false
• 关键词: STTR; Phase; mesh; free; sling

The broader impact/commercial potential of this Small Business Technology Transfer Program (STTR) Phase I project is to advance a new women's health device to address stress urinary incontinence (SUI). The estimated lifetime risk of urinary incontinence surgery in women is 20% by age 80, with 41.3 million women estimated to suffer from urinary incontinence by 2050. The associated market had an estimated value of $1.6 billion in 2018, with projections to reach $2.3 billion by 2026. The proposed device addresses this need and improves clinical outcomes. This Small Business Technology Transfer Program (STTR) Phase I project aims to demonstrate the mechanical feasibility of a non-mesh surgical device by developing the first viable prototype and iterating elements of the device design based on mechanical tests (strength, stiffness, and durability) of each of the device’s components (i.e., the elastic band, the tissue anchor, and the bone anchor) and the device as a whole. The technical objectives include using computational simulations to assess the material stiffness and optimize placement, preparing and testing materials, and ensuring strength and longevity of the assembled device.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业技术转让计划（STTR）第一阶段项目的更广泛的影响/商业潜力是推进一种新的女性健康设备，以解决压力性尿失禁（SUI）。 据估计，到80岁时，女性尿失禁手术的终生风险为20%，到2050年，估计将有4130万女性患有尿失禁。 2018年，相关市场的估计价值为16亿美元，预计到2026年将达到23亿美元。 申报器械满足了这一需求，并改善了临床结局。本小企业技术转让计划（STTR）第一阶段项目旨在通过开发第一个可行的原型并基于器械每个组件（即，弹性带、组织锚和骨锚）和装置作为一个整体。技术目标包括使用计算机模拟来评估材料刚度和优化放置，准备和测试材料，并确保组装设备的强度和寿命。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。