Optische Bildgebungseinheit

光学成像单元

• 批准号: 250085529
• 金额: --
• 依托单位: Medizinische Fakultät und Universitätsklinikum Tübingen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/250085529?language=en
• 关键词: Optische; Bildgebungseinheit

The Department of Preclinical Imaging and Radiopharmacy currently employs about 57 scientists, engineers, technologists and administrative personell. The focus of our research is imaging science and we are primarily active in all fields of biomedical science, including oncology, neurology, immunology, infectious diseases and cardiology as well as detector development for positron emission tomography (PET) and radiotracer development. For this field of research we utilize non-invasive molecular and functional imaging methods such as optical imaging, PET, magnetic resonance tomography (MRT) and computer tomography as well as the combination of those systems as multimodality imaging devices. A large part of our research depends on molecular imaging with fluorescence probes and bioluminescence imaging. We ask for a new optical imaging device as our current optical imaging scanner, which is already seven years old, reveals significant limitations in sensitivity, signal-to-noise ratio, options in image analysis and quantification as well as handling and high throughput studies. With this application we provide supportive data about the fields on which we focused our optical imaging research so far and what other projects we will perform with the new equipment in the future.

临床前成像和放射性药物学部门目前雇用了大约57名科学家，工程师，技术人员和行政人员。我们的研究重点是成像科学，我们主要活跃于生物医学科学的所有领域，包括肿瘤学，神经学，免疫学，传染病和心脏病学以及正电子发射断层扫描（PET）和放射性示踪剂开发的探测器开发。对于这一研究领域，我们利用非侵入性分子和功能成像方法，如光学成像，PET，磁共振断层扫描（MRT）和计算机断层扫描以及这些系统的组合作为多模态成像设备。我们的研究很大一部分依赖于荧光探针和生物发光成像的分子成像。我们需要一种新的光学成像设备，因为我们目前的光学成像扫描仪已经使用了七年，在灵敏度、信噪比、图像分析和量化的选择以及处理和高通量研究方面存在明显的局限性。通过该应用程序，我们提供了有关我们迄今为止专注于光学成像研究的领域的支持数据，以及我们将来将使用新设备执行的其他项目。

项目成果

Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions

• DOI: 10.7150/thno.31037
• 发表时间: 2019-05
• 期刊: Theranostics
• 影响因子: 12.4
• 作者: J. Schwenck;A. Maurer;B. Fehrenbacher;R. Mehling;P. Knopf;N. Mucha;D. Haupt;K. Fuchs;C. Griessinger;Daniel Bukala;J. Holstein;M. Schaller;Irene Gonzalez Menendez;K. Ghoreschi;L. Quintanilla‐Martinez;M. Gütschow;S. Laufer;T. Reinheckel;M. Röcken;H. Kalbacher;B. Pichler;M. Kneilling

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent.

• DOI: 10.3791/55180
• 发表时间: 2017-05
• 期刊: Journal of visualized experiments : JoVE
• 作者: J. Schwenck;F. Maier;M. Kneilling;S. Wiehr;K. Fuchs