Research Initiation Award: Targeting Pyocyanin Production to Study Virulence Gene Regulation in Pseudomonas Aeruginosa
研究启动奖:以绿脓素生产为目标研究铜绿假单胞菌毒力基因调控
基本信息
- 批准号:2200642
- 负责人:
- 金额:$ 28.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The Historically Black Colleges and Universities Undergraduate Program (HBCU-UP) through Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty member's research capability and effectiveness and improve research and teaching at the home institution. This award to Fayetteville State University supports faculty and undergraduate research experiences investigating the molecular mechanisms of gene expression. Specifically, the project seeks to examine the regulatory pathways of pyocyanin (virulence factor) production in Pseudomonas aeruginosa. Pyocyanin is highly regulated, extracellularly secreted, and easily quantifiable, making it an ideal target for studying gene regulation.P. aeruginosa is a Gram-negative opportunistic bacterium that is ubiquitous in nature, ranging from soil to jet fuel. Due to the vast range of mechanisms necessary for P. aeruginosa survival, adaption, and antibiotic resistance, there is a need to better understand and explore these regulatory pathways and elucidate the molecular underpinnings. This project targets pyocyanin production to study virulence gene regulation and discover novel regulatory pathways. Specifically, this project aims to: 1) characterize the role that environmental factors play in pyocyanin regulation, 2) determine how various transcription factors and small molecules affect pyocyanin regulation, and 3) explore if the regulatory pathways of pyocyanin can be applied to other virulence factors in P. aeruginosa. This study will advance our understanding of pyocyanin regulation and has the potential to serve as a roadmap for understanding how other virulence factors are regulated. The data generated from this work will aid future experimental exploration of pyocyanin and the regulation of other virulence genes in P. aeruginosa. Ultimately, the implementation of this research project will be centered around teaching and training undergraduate students in hypothesis-driven research experiences. Students will develop skills in experimental design, critical reading, and understanding primary literature, enhancing their preparation for graduate school and/or the STEM workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
通过研究启动奖的历史黑人学院和大学本科课程(HBCU-UP)为历史黑人学院和大学的初级和职业生涯中期教师提供支持,这些教师正在建立新的研究项目或重新定向和重建现有的研究项目。预计该奖项有助于进一步提高教师的研究能力和有效性,并改善所在机构的研究和教学。这一奖项授予费耶特维尔州立大学,支持教职员工和本科生研究基因表达的分子机制。具体地说,该项目试图研究铜绿假单胞菌产生绿脓素(毒力因子)的调控途径。绿脓杆菌是一种革兰氏阴性的机会细菌,在自然界中普遍存在,从土壤到喷气燃料。由于铜绿假单胞菌的生存、适应和抗生素耐药所必需的广泛机制,有必要更好地了解和探索这些调控途径,并阐明其分子基础。本项目以绿青素的生产为目标,研究毒力基因调控,发现新的调控途径。具体地说,本项目的目的是:1)研究环境因素在绿脓菌素调控中的作用,2)确定各种转录因子和小分子如何影响绿脓菌素调控,3)探索绿脓菌素的调控途径是否可以应用于铜绿假单胞菌的其他毒力因子。这项研究将促进我们对绿青素调控的理解,并有可能成为了解其他毒力因子是如何调控的路线图。这项工作产生的数据将有助于未来绿脓菌素的实验探索和对铜绿假单胞菌其他毒力基因的调控。最终,这项研究项目的实施将围绕本科生在假设驱动的研究经验方面进行教学和培训。学生将发展实验设计、批判性阅读和理解主要文献的技能,加强他们为研究生院和/或STEM工作人员的准备。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Justin Graham其他文献
Water velocity preferences of Coho Salmon during the parr-smolt transformation
- DOI:
10.1007/s10641-010-9619-8 - 发表时间:
2010-03-11 - 期刊:
- 影响因子:1.800
- 作者:
Shana M. Katzman;Jonathan Greathouse;Julie M. Roessig;Justin Graham;Dennis E. Cocherell;Joseph J. Cech - 通讯作者:
Joseph J. Cech
Bioterrorism preparedness and response: use of information technologies and decision support systems.
生物恐怖主义的准备和应对:信息技术和决策支持系统的使用。
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
D. Bravata;K. McDonald;D. Owens;D. Buckeridge;C. Haberland;C. Rydzak;M. Schleinitz;Wendy M. Smith;H. Szeto;D. Wilkening;M. Musen;B. Duncan;B. Nouri;MB Dangiolo;Hau Liu;S. Shofer;Justin Graham;Sheryl M. Davies - 通讯作者:
Sheryl M. Davies
Conceptual Heterogeneity Complicates Automated Syndromic Surveillance for Bioterrorism
概念异质性使生物恐怖主义的自动症状监测变得复杂
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
Justin Graham;D. Buckeridge;Michael Choy;M. Musen - 通讯作者:
M. Musen
A knowledge-based method for surveillance
- DOI:
10.1007/bf02416920 - 发表时间:
2003-03-01 - 期刊:
- 影响因子:4.100
- 作者:
David L. Buckeridge;Martin O’Connor;Justin Graham;Michael K. Choy;Zachary Pincus;Mark Musen - 通讯作者:
Mark Musen
Justin Graham的其他文献
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