T1- and T2-Mapping for prediction of remodeling in patients with acute myocardial infarction

T1 和 T2 映射用于预测急性心肌梗死患者的重构

• 批准号: 251229616
• 负责人: Professor Dr. Gunnar Lund
• 金额: --
• 依托单位: Universitäres Herz- und Gefäßzentrum Hamburg (UHZ)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251229616?language=en
• 关键词: T1; T2; Mapping; prediction; remodeling

The aim of the proposed work is to analyze the prognostic value of T1- and T2-mapping in comparison to standard MRI to predict progressive left ventricular remodeling. Standard MRI includes T2w-, late gadolinium enhancement (LGE)- and Cine-MRI. The study focus on patients with acute ST segment elevation myocardial infarction (STEMI). These patients will be studied prospectively and serially using T1- and T2-mapping. In patients with STEMI T1- and T2-mapping will be used to study the impact of the infarct and the peri-infarct zone for the development of left ventricular remodeling. A special focus will be the time course of the pre-contrast T1- and T2-times in different myocardial areas to understand the impact of edema in the development in global remodeling. Normal data will be established by studying age and sex-matched healthy volunteers to develop cutoff values for T1- and T2-times.

本研究的目的是分析T1和t2成像与标准MRI的预后价值，以预测进行性左心室重构。标准MRI包括T2w-，晚期钆增强(LGE)-和Cine-MRI。研究对象为急性ST段抬高型心肌梗死（STEMI）患者。这些患者将采用T1和t2定位进行前瞻性和连续性研究。STEMI患者的T1和t2制图将用于研究梗死区和梗死周围区对左室重构发展的影响。我们将特别关注不同心肌区域对比前T1和t2次的时间过程，以了解水肿在整体重构发展中的影响。正常数据将通过研究年龄和性别匹配的健康志愿者来建立，以确定T1和t2次的临界值。