NSF Postdoctoral Fellowship in Biology: Effects of Temporal Variation on Genomic Architecture and Phenotype in a Classic Hybrid Zone

NSF 生物学博士后奖学金：时间变异对经典杂交区基因组结构和表型的影响

• 批准号: 2208825
• 负责人: Thomas Firneno
• 金额: $ 13.8万
• 依托单位: Firneno, Thomas J
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2208825&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; Effects

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2022, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the Fellow that will contribute to the area of Rules of Life in innovative ways. The research component of this fellowship investigates the repeatability and predictability of evolutionary processes across whole genomes in hybrid zones. Hybrid zones offer a unique opportunity to examine how selection acts on various axes in natural populations. Through an integrative genotype-phenotype approach, this research will inspire new avenues of research in speciation, hybridization, and evolutionary biology; it will also hopefully answer a decades-old question: How predictable are evolutionary outcomes? Through this project, the Fellow will provide (1) critical training and mentoring to undergraduates (both in the laboratory and through the development of a course-based undergraduate research experience); (2) meaningful outreach opportunities to increase public engagement with, and appreciation for, nature and science; and (3) an opportunity for individuals underrepresented in STEM disciplines, including LGBTQ+ researchers, to present research findings and discuss their professional journeys. The objective of this proposal is to test the hypothesis that selection on recombinant genomes is repeatable over different temporal scales. To do so, the proposed research integrates field-based collections, natural history, classic and cutting-edge genomic methods, genotype-phenotype associations, and computational biology. The Fellow will use historic and contemporary sampling, as well as replicate sampling across the hybrid zone that came in contact at different times between North American field crickets in order to understand variation in selection on genomic and phenotypic variables across temporal scales. Key scientific outcomes will include (1) the integration of the genomic and phenotypic patterns of temporal variation in selection and (2) a test of the repeatability of selection on recombinant genomes. More broadly, the Fellow will broadly engage academic students and the public in science, critical thinking, and an appreciation for nature; this includes increasing the visibility and involvement of LGBTQ+ researchers and others who are underrepresented in STEM fields. The Fellow will also receive critical new scientific training that will add skill sets in genomic, molecular, and computational laboratory techniques.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该行动资助了美国国家科学基金会2022财年生物学博士后研究奖学金，研究基因组，环境和表型之间相互作用的生命规则的综合研究。该奖学金支持将以创新方式为《生活规则》领域作出贡献的研究员的研究和培训。该奖学金的研究部分调查了杂交区域中整个基因组进化过程的可重复性和可预测性。杂交区提供了一个独特的机会来研究选择是如何在自然种群的各个轴上起作用的。通过整合基因型-表型方法，本研究将激发物种形成、杂交和进化生物学研究的新途径；它也有望回答一个几十年来的问题：进化结果有多可预测？通过该项目，研究员将提供(1)对本科生的关键培训和指导（包括在实验室和通过基于课程的本科生研究经验的开发）；(2)有意义的外展机会，以增加公众对自然和科学的参与和欣赏；(3)为STEM学科中代表性不足的个人提供机会，包括LGBTQ+研究人员，展示研究成果并讨论他们的职业生涯。本提案的目的是测试重组基因组的选择在不同的时间尺度上是可重复的假设。为此，拟议的研究整合了基于实地的收集、自然历史、经典和前沿的基因组方法、基因型-表型关联和计算生物学。研究员将使用历史和当代采样，以及在北美蟋蟀之间不同时间接触的杂交区重复采样，以了解基因组和表型变量在时间尺度上的选择变化。关键的科学成果将包括：(1)整合选择中时间变异的基因组和表型模式；(2)对重组基因组选择的可重复性进行测试。更广泛地说，该奖学金将广泛地吸引学术学生和公众参与科学、批判性思维和对自然的欣赏；这包括提高LGBTQ+研究人员和其他在STEM领域代表性不足的人的知名度和参与度。该研究员还将接受重要的新科学培训，以增加基因组、分子和计算实验室技术方面的技能。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。