Virale Zweckentfremdung des Proteins DDB1 als Evasionsstrategie gegen angeborene Immunität (A07)

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Project A7 will analyze how chronic viruses counteract IFN responses. Chronic viruses often utilize the DDB1 and Cullin-containing ubiquitin ligase pathway to degrade molecules of the IFN signaling pathway or IFN-induced restriction factors. Also HIV (vpx) and HBV (HBx) proteins exploit this pathway, which will be analyzed in greater detail. Most importantly, the PIs of project A7 use a small molecule inhibitor of the Cullin enzymatic activity that shows high antiviral activity against several viruses. Its therapeutic effect against FV, HIV, HTLV, HCV and HBV will be tested in vitro and if possible in vivo. Furthermore, the antiviral profile of IFNγ will be analyzed in these studies. The group defined a pattern of IFNγ induced and repressed proteins that allows the detailed characterization of their antiviral activity against retroviruses.