MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols

该奖项全部或部分由《2021年美国救援计划法案》（公法117-2）资助。meelecio Perea被授予NSF数学和物理科学提升博士后研究奖学金（NSF MPS-Ascend），以开展与扩大STEM中代表性不足的群体参与相关的研究和活动计划。Perea博士的研究项目名为“MPS-Ascend：镍/光氧化还原催化C(sp3) -C （sp3）在烷基卤化物和活化醇之间的交叉偶联”，由一位赞助科学家指导。该奖学金的主办机构是加州大学洛杉矶分校，赞助科学家是阿比盖尔·多伊尔博士。本研究旨在探索镍与光氧化还原催化的结合是实现C（sp3）中心功能化的有效策略。提出的工作旨在以外消旋形式发展烷基-烷基偶联；进行机制调查，这将提供洞察交叉耦合的性质；并提供反应范围的评估及其对医学相关转化的潜在适用性。这项工作将以多变量线性回归分析的形式进行计算建模。PI计划通过参与美国国家科学基金会研究生教育联盟和加州大学洛杉矶分校教授研究型大学联盟，指导其他历史上被排斥背景的研究生和本科生。该联盟旨在通过支持少数族裔背景的博士前和博士后研究人员来增强学术界的多样性。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Melecio Perea is awarded a NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM. This fellowship to Dr. Perea supports the research project entitled "MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols", under the mentorship of a sponsoring scientist. The host institution for the fellowship is the University of California Los Angeles, and the sponsoring scientist is Dr. Abigail Doyle. The proposed work intends to explore the merger of nickel and photoredox catalysis which is an effective strategy for functionalizing C(sp3) centers. The proposed work intends to develop alkyl-alkyl coupling in racemic form; pursue mechanistic investigations which will provide insight into the nature of the cross coupling; and provide an evaluation of the scope of the reaction and its potential applicability to medicinally relevant transformations. The work will be complemented by computational modeling in the form of multivariant linear regression analysis. The PI intends to mentor other graduate and undergraduate students from historically excluded backgrounds through participation in the NSF Alliance for Graduate Education and the Professoriate Research University Alliance at UCLA. This alliance aims to enhance diversity in academia by supporting predoctoral and postdoctoral researchers from minority backgrounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.