MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols

MPS-Ascend：镍/光氧化还原催化的 C(sp3)→C(sp3) 烷基卤化物和活化醇之间的交叉偶联

• 批准号: 2213210
• 负责人: Melecio Perea
• 金额: $ 30万
• 依托单位: Perea, Melecio
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213210&HistoricalAwards=false
• 关键词: MPS; Ascend; Nickel; Photoredox; Catalyzed

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Melecio Perea is awarded a NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM. This fellowship to Dr. Perea supports the research project entitled "MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols", under the mentorship of a sponsoring scientist. The host institution for the fellowship is the University of California Los Angeles, and the sponsoring scientist is Dr. Abigail Doyle. The proposed work intends to explore the merger of nickel and photoredox catalysis which is an effective strategy for functionalizing C(sp3) centers. The proposed work intends to develop alkyl-alkyl coupling in racemic form; pursue mechanistic investigations which will provide insight into the nature of the cross coupling; and provide an evaluation of the scope of the reaction and its potential applicability to medicinally relevant transformations. The work will be complemented by computational modeling in the form of multivariant linear regression analysis. The PI intends to mentor other graduate and undergraduate students from historically excluded backgrounds through participation in the NSF Alliance for Graduate Education and the Professoriate Research University Alliance at UCLA. This alliance aims to enhance diversity in academia by supporting predoctoral and postdoctoral researchers from minority backgrounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分根据2021年美国救援计划法案（公法117-2）资助。Melecio Perea被授予NSF数学和物理科学上升博士后研究奖学金（NSF MPS-Ascend），以开展与扩大STEM代表性不足的群体参与有关的研究和活动计划。Perea博士的奖学金支持题为“MPS-Ascend：镍/光氧化还原催化的C（sp3）-C（sp3）卤代烷和活性醇之间的交叉偶联”的研究项目，该项目由赞助科学家指导。该研究金的主办机构是加州洛杉矶大学，赞助科学家是阿比盖尔·道尔博士。 本论文旨在探索镍与光氧化还原催化的结合，这是一种有效的C（sp3）中心功能化策略。拟议的工作旨在开发外消旋形式的烷基-烷基偶联;进行机理调查，这将提供深入了解交叉偶联的性质;并提供反应范围及其对医学相关转化的潜在适用性的评估。这项工作将辅之以多元线性回归分析形式的计算建模。PI打算通过参与NSF研究生教育联盟和加州大学洛杉矶分校的教授研究型大学联盟，指导来自历史上被排除在外的背景的其他研究生和本科生。该联盟旨在通过支持来自少数民族背景的博士前和博士后研究人员来增强学术界的多样性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。