STTR Phase I: A Novel Prescription Process that Customizes Prosthetic Feet for Individual Patients

STTR 第一阶段：为个体患者定制假足的新颖处方流程

• 批准号: 2233114
• 负责人: Harrison Bartlett
• 金额: $ 27.5万
• 依托单位: LITTLE ROOM INNOVATIONS, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2233114&HistoricalAwards=false
• 关键词: STTR; Phase; Novel; Prescription; Process

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel process for providing customized prosthetic feet. Current prescription methods match patients with prosthetic feet designs based on the patient’s weight and level of physical activity. However, this method often neglects patient variabilities in terms of posture and walking gait and results in suboptimal force distribution and a mismatch in biomechanics. These problems, in turn, result in a multitude of potential chronic issues including issues with gait, balance. and pain. This proposed system aims to develop a novel fitting system and fabrication process to provide customized prosthetic feet based on optimized mechanical stress distribution models. The system aims to benefit the 420,000 highly active US patients who utilize prosthetic feet each year. This STTR Phase I project will address a clinical need by developing a novel prescription approach to developing custom prosthetic feet. The novel process utilizes a prosthetic foot model with adjustable stiffness properties in conjunction with an optimization algorithm to determine individual patient’s customized prosthetic foot settings. Custom prosthetic feet will be fabricated and fitted for use in individual patients. The prosthetics will then be validated in a limited proof of concept study to demonstrate improvements to kinematic and kinetic behaviors. The goals are to closely match the participant's intact ankle and foot measurements and to improve patient satisfaction outcomes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业技术转移（STTR）I期项目的更广泛的影响/商业潜力是提供定制假肢的新过程。目前的处方方法根据患者的体重和体育锻炼水平与假肢设计相匹配。但是，这种方法通常会忽略患者的姿势和步行收集方面的变异性，并导致次优的力分布和生物力学的不匹配。反过来，这些问题导致了许多潜在的慢性问题，包括答案问题，平衡。和痛苦。该提出的系统旨在开发一种新型的拟合系统和制造过程，以根据优化的机械应力分配模型提供定制的假肢脚。该系统旨在使每年使用假肢的420,000名高活跃的美国患者受益。这个STTR I期项目将通过开发一种新的处方方法来开发定制的假肢，以满足临床需求。新型过程利用具有可调节刚度特性的假肢模型与优化算法一起确定个体患者的自定义假体脚部设置。定制的假肢将被制造并安装在个别患者中。然后，将在有限的概念验证研究中对假肢进行验证，以证明运动和动力学行为的改进。目标是与参与者完整的脚踝和脚步测量并提高患者满意度的成果密切相匹配。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响来评估，被认为是宝贵的支持。