RUI: CAS-SC: Promoting Group-Transfer Reactions at Metal/Main-Group Bonds

RUI：CAS-SC：促进金属/主族键的基团转移反应

• 批准号: 2244969
• 负责人: Matthew Whited
• 金额: $ 35.59万
• 依托单位: Carleton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2244969&HistoricalAwards=false
• 关键词: RUI; CAS; SC; Promoting; Group

With support from the Chemical Synthesis Program of the Chemistry Division, Matthew T. Whited and his research group of undergraduate students at Carleton College are developing new applications of metal complexes featuring bonds to heavy non-metal elements such as silicon. These compounds are designed to provide synergistic interaction between the main group atom and the metal. This enables the compound to bring together different groups and enable reactions between them. The project will develop systems where reactive chemical fragments are attached to inexpensive and readily abundant substrates to afford products with applications in both that bulk and fine chemical arenas. This approach also seeks to replace expensive, rare metals with earth abundant ones in catalysis. The project will provide a training ground for undergraduate researchers and enable expanded outreach to high school students in Northfield, MN and Faribault, MN on topics related to chemical synthesis and X-ray crystallography.This project seeks to develop the chemistry of late-metal/main-group interactions by exploring metal-silicon single and multiple bonds as platforms for transfer of reactive nitrene, carbene, and related groups to organic substrates. Preliminary findings have shown that these “electronically frustrated” linkages can enable dual-site catalysis whereby the two sites (metal and main-group element) interact with different substrates to bring them together, but the generality of this strategy has not been demonstrated. Such an approach serves to avoid problems of poisoning present in many catalysts and also provides a distinct approach to using earth abundant metals such as iron, cobalt, and nickel in group-transfer catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成项目的支持下，Matthew T.怀特和他在卡尔顿学院的研究小组正在开发金属络合物的新应用，这些金属络合物的特点是与硅等重非金属元素键合。这些化合物被设计成在主族原子和金属之间提供协同相互作用。这使得化合物能够将不同的基团聚集在一起，并使它们之间发生反应。 该项目将开发一种系统，将反应性化学碎片附着在廉价且易于丰富的基质上，以提供在散装和精细化学品领域都有应用的产品。这种方法还试图在催化剂中用地球丰富的金属取代昂贵的稀有金属。该项目将为本科生研究人员提供一个培训基地，并使扩大外展到高中学生在Northfield，MN和Faribault，MN有关的化学合成和X-射线crystallography.This项目的主题旨在通过探索金属硅单键和多键作为平台，用于转移反应性氮烯，卡宾和相关基团的有机基板，以发展后期金属/主基团相互作用的化学。初步研究结果表明，这些“电子受挫”的联系，可以使双位点催化，其中两个网站（金属和主族元素）与不同的基板相互作用，使他们在一起，但这种策略的普遍性尚未得到证明。这种方法可以避免许多催化剂中存在的中毒问题，也为在基团转移催化中使用地球上丰富的金属（如铁、钴和镍）提供了一种独特的方法。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。