NSF Postdoctoral Fellowship in Biology: Coalescent Modeling of Sex Chromosome Evolution with Gene Flow and Analysis of Sexed-versus-Gendered Effects in Human Admixture
NSF 生物学博士后奖学金:性染色体进化与基因流的合并模型以及人类混合中性别与性别效应的分析
基本信息
- 批准号:2305910
- 负责人:
- 金额:$ 24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Fellowship Award
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2023, Broadening Participation of Groups Underrepresented in Biology. The goal of this project is to generate insights about how events in human evolutionary history, such as interactions between populations, can be inferred from modern genome data. This work seeks to deepen the understanding of biological and social factors that have shaped human history. The research will also generate theories to contextualize identity categories within human evolutionary genomics, and further develop approaches to help understand human diversity. In addition, this project will provide the fellow with training in the mathematical and computational techniques used in population genetics, and promote the fellow’s activities in public outreach, mentoring of trainees, and fostering inclusive community within Brown University’s postdoctoral body.This project will give the fellow an opportunity to continue developing skills in theoretical population genetics, with a particular focus on coalescent theory and simulations. The project will include the development of a coalescent model which can describe the evolution of non-autosomal chromosomes with inversions, a critical component of modeling patterns of bias in admixture. In addition, the fellow will use forward-time population genetic simulations of gene flow between populations to generate expectations of patterns of relatedness under novel models of gene-by-environmental and cultural determination of migration probability. The fellow will then use the results of the theory and simulation work to generate insights into how human demographic history has been impacted by cultural and biological factors. This project will build on work in science and technology studies, mathematics, and evolutionary biology to generate an interdisciplinary understanding of how populations evolve in the face of admixture and gene flow. Finally, throughout the course of the project, the fellow will support underrepresented students in STEM through teaching, mentorship, and community organizing in collaboration with existing groups at Brown University.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项行动资助了2023财年的NSF生物学博士后研究奖学金,扩大了生物学中代表性不足的群体的参与。该项目的目标是了解人类进化史上的事件,例如种群之间的相互作用,如何从现代基因组数据中推断出来。这项工作旨在加深对塑造人类历史的生物和社会因素的理解。该研究还将产生理论,在人类进化基因组学中将身份类别置于背景中,并进一步开发有助于理解人类多样性的方法。此外,该项目将为研究员提供群体遗传学中使用的数学和计算技术方面的培训,并促进研究员在公共宣传、指导受训人员和在布朗大学博士后机构内培养包容性社区方面的活动。该项目将使研究员有机会继续发展理论群体遗传学方面的技能,特别关注聚结理论和模拟。该项目将包括开发一个结合模型,该模型可以描述具有倒位的非常染色体的进化,这是混合物中偏倚模式建模的关键组成部分。此外,该研究员将使用人口之间基因流动的前瞻性人口遗传模拟,以产生对迁移概率的基因-环境和文化决定的新模型下的相关模式的预期。然后,研究员将使用理论和模拟工作的结果来深入了解人类人口历史如何受到文化和生物因素的影响。该项目将建立在科学和技术研究,数学和进化生物学的工作,以产生一个跨学科的理解人口如何在面对混合和基因流的演变。最后,在整个项目过程中,该研究员将通过与布朗大学现有团体合作,通过教学、指导和社区组织来支持STEM领域代表性不足的学生。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Miriam Miyagi其他文献
How many ecological niches are defined by the superabundant marine microbe Prochlorococcus?
丰富的海洋微生物原绿球藻定义了多少生态位?
- DOI:
10.1101/2022.11.29.517206 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Miriam Miyagi;Maike L. Morrison;M. Kirkpatrick - 通讯作者:
M. Kirkpatrick
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