MRI: Acquisition of Hydrogen/Deuterium eXchange Mass Spectrometer

肯塔基大学获得氢/氘交换（HDX）质谱分析系统。HDX是一项尖端技术，它将使研究人员从对生物分子结构的静态理解转向对大分子和大分子相互作用的动态理解。该系统将为肯塔基大学、阿巴拉契亚地区以及其他合作研究人员和机构的研究人员提供一种独特而强大的研究技术的关键能力。购置该系统将与在英联邦内外改进教育和培训的倡议结合起来。培训活动包括为学生和教师开设的课程。此外，通过包括pui的外展，与本科研究经验（REU）项目的协同作用，以及高中STEM外展和教育的参与，将最大限度地发挥收购的影响。总体而言，这也将导致发展一支多样化和具有全球竞争力的STEM劳动力队伍，并提高公众的科学素养和对科学技术的参与。最近的进展将HDX定位为一种强大的通用技术，基于测量不同溶剂可及性来解决关键的结构、生物、生物物理和材料问题。新的HDX系统将服务于广泛的用户，并使探索基础生物和材料系统的研究融合在一起。新系统支持的研究课题包括葡聚糖二激酶在淀粉代谢中的功能、基于黄素的代谢研究、病毒膜融合、DNA修复机制、微管组装以及一系列其他有趣的课题。生成的数据将推动关键领域的发展，包括生物化学、结构生物学、生物科学、生物物理学和材料。为了确保从HDX设备中获得最大的收益，研究人员将确保通过同行评审的出版物、科学会议上的报告和向社区的报告来传播知识。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the University of Kentucky to acquire a Hydrogen/Deuterium eXchange (HDX) Mass Spectrometry System. HDX is a cutting-edge technique that will allow researchers to move from static understanding of biomolecule structure to a dynamic view of macromolecules and macromolecular interactions. The system will provide the critical capabilities of a unique and powerful research technology to researchers at the University of Kentucky, to the Appalachian region, and other partner investigators and institutions. Acquisition of the system will be coupled with initiatives to improve education and training in the Commonwealth and beyond. The training activities include classes for both students and faculty. Additionally, outreach through inclusion of PUIs, synergy with Research Experience for Undergraduate (REU) programs, and involvement of High School STEM outreach and education will maximize the impact of the acquisition. Overall, this will also result in development of a diverse and globally competitive STEM workforce and increasing public scientific literacy and engagement with science technology. Recent advances have positioned HDX as a powerful general technology based on measuring differential solvent accessibility to address key structural, biological, biophysical, and materials questions. The new HDX system will serve a broad range of users and enable a convergence of research that probes fundamental biological and material systems. Research topics supported by the new system include glucan dikinase function in starch metabolism, flavin-based metabolism studies, viral membrane fusion, DNA repair mechanisms, microtubule assembly, and a range of other interesting subjects. Data generated will advance key fields including biochemistry, structural biology, biological sciences, biophysics, and materials. To ensure maximum benefit from the HDX equipment, the researchers will ensure dissemination of knowledge through peer-reviewed publications, presentations at scientific meetings, and presentations to the community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.