LEAPS-MPS: Cooperative Transformations of N-Heterocycles with Heterometallic Complexes

在这个由美国国家科学基金会化学部门管理的项目中，德克萨斯大学格兰德谷分校的Manar Shoshani教授和他的学生将研究异金属Ni-Lewis酸配合物对n -杂环的活化和功能化。Shoshani教授和他的团队正专注于开发新的复合物，以获得更具挑战性和更具选择性的转化。该项目支持继续与来自里约热内卢格兰德山谷的高中生进行接触，该地区超过90%的人是西班牙裔。外展活动包括建立由Shoshani教授和他的小组成员领导的教育化学示范站。Shoshani教授和他的团队成员的目标是对定义明确的异质金属Ni-Al氢化物配合物进行深入的反应性和机理研究，以详细了解n -杂环功能化的运作机制。该团队的目标是利用多金属氢化物基序的模块化特性，并进行一系列结构-功能研究，以确定指导和切换选择性的新方法，以及获得更多减少的n -杂环支架。Shoshani教授和他的团队也在探索新的基序，以进一步利用富电子和贫电子金属中心之间桥接氢化物的反应性质，进一步挑战协同转化。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

In this project managed by the Chemistry Division at NSF, Professor Manar Shoshani and his students at the University of Texas Rio Grande Valley will study the activation and functionalization of N-heterocycles by heterometallic Ni-Lewis Acid complexes. Professor Shoshani and his group are focusing on the development of new complexes to access more challenging as well as more selective transformations. This project supports continued outreach with high school students from the Rio Grande Valley, an area comprising greater than 90 percent Hispanic individuals. The outreach events include setting up stations incorporating educational chemistry demonstrations led by Professor Shoshani and his group members. Professor Shoshani and his group members aim to carry out thorough reactivity and mechanistic studies with well-defined heterometallic Ni-Al hydride complexes to develop a detailed understanding of the operating mechanism of N-heterocycle functionalization. The team’s goal is to leverage the modular nature of the multimetallic hydride motifs and conduct a set of structure-function studies to identify new ways to guide and toggle selectivity, as well gain access to more reduced N-heterocyclic scaffolds. Professor Shoshani and his group are also exploring new motifs to further leverage the reactive nature of bridged hydrides between electron rich and electron poor metal centers towards further challenging cooperative transformations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.