LEAPS-MPS: Cooperative Transformations of N-Heterocycles with Heterometallic Complexes

LEAPS-MPS：N-杂环与异金属配合物的协同转化

• 批准号: 2316582
• 负责人: Manar Shoshani
• 金额: $ 25万
• 依托单位: The University of Texas Rio Grande Valley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316582&HistoricalAwards=false
• 关键词: LEAPS; MPS; Cooperative; Transformations; Heterocycles

In this project managed by the Chemistry Division at NSF, Professor Manar Shoshani and his students at the University of Texas Rio Grande Valley will study the activation and functionalization of N-heterocycles by heterometallic Ni-Lewis Acid complexes. Professor Shoshani and his group are focusing on the development of new complexes to access more challenging as well as more selective transformations. This project supports continued outreach with high school students from the Rio Grande Valley, an area comprising greater than 90 percent Hispanic individuals. The outreach events include setting up stations incorporating educational chemistry demonstrations led by Professor Shoshani and his group members. Professor Shoshani and his group members aim to carry out thorough reactivity and mechanistic studies with well-defined heterometallic Ni-Al hydride complexes to develop a detailed understanding of the operating mechanism of N-heterocycle functionalization. The team’s goal is to leverage the modular nature of the multimetallic hydride motifs and conduct a set of structure-function studies to identify new ways to guide and toggle selectivity, as well gain access to more reduced N-heterocyclic scaffolds. Professor Shoshani and his group are also exploring new motifs to further leverage the reactive nature of bridged hydrides between electron rich and electron poor metal centers towards further challenging cooperative transformations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由NSF化学部管理的项目中，德克萨斯大学格兰德河谷的Manar Shoshani教授和他的学生将研究通过异金属Ni-Lewis酸络合物活化和官能化N-杂环。Shoshani教授和他的团队正专注于开发新的复合物，以获得更具挑战性和更具选择性的转化。该项目支持继续与来自格兰德河山谷的高中生进行外联，该地区90%以上是西班牙裔。外展活动包括设立由Shoshani教授及其小组成员领导的教育化学示范站。Shoshani教授和他的小组成员的目标是用定义明确的异金属Ni-Al氢化物络合物进行彻底的反应性和机理研究，以详细了解N-杂环官能化的操作机制。该团队的目标是利用多金属氢化物基序的模块化性质，并进行一系列结构-功能研究，以确定指导和切换选择性的新方法，以及获得更多还原的N-杂环支架。Shoshani教授和他的团队还在探索新的主题，以进一步利用富电子和贫电子金属中心之间的桥接金属的反应性质，实现进一步具有挑战性的合作转化。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。