Postdoctoral Fellowship: OPP-PRF: Identifying Central and Peripheral Thermosensors in Eurythermal and Stenothermal Arctic Fishes
博士后奖学金:OPP-PRF:识别广温和窄温北极鱼类的中央和外周热传感器
基本信息
- 批准号:2317970
- 负责人:
- 金额:$ 35.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2024
- 资助国家:美国
- 起止时间:2024-03-01 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The Arctic Ocean is warming at a rate up to seven times the global average, endangering and shifting key subsistence and commercial fisheries. Fish populations are stressed by warming and simultaneously by ocean acidification and oxidation. This study aims to characterize the evolution of proteins that integrate signals of warming, changing pH, and oxidation in the sensory systems of three species of Arctic and sub-Arctic fish: the Arctic cod (Boreogadus saida), saffron cod (Eleginus gracilis), and Atlantic cod (Gadus morhua). Studying the evolution of these sensory mechanisms provides insight into the sensitivity and responses of fish to climate change. This work also has implications for understanding protein-induced pain, inflammation, and itch responses in humans. During the course of this research, two undergraduates from underrepresented groups in science will be mentored through a summer research program. A K-12 lesson plan will be developed that combines the insights from this project with Alaska Native science curricula and values and Next Generation Science Standards. A major goal of this work is to generate high-quality genomic and transcriptomic data across stenothermal and eurythermal Arctic fish species, but also across central thermosensory nervous tissue, peripheral thermosensory nervous tissue, non-thermosensory nervous tissue, and non-nervous somatic tissue. These data will be generated using a combination of 3rd (IsoSeq) and 2nd (RNASeq) generation sequencing technologies and be used to characterize transient receptor potential (TRP) channel sequences and expression patterns. TRP channel profiles will be compared using in silico tests of regulatory and structural evolution, including predicting protein structure using AlphaFold2. These profiles will be compared between species, tissues, and to stenothermal Antarctic fishes to investigate central and peripheral mechanisms of temperature sensation in fishes and convergent adaptation to cold. This work is the first investigation into the evolution of molecular thermosensor proteins in any Arctic species and the first to target mechanisms of thermosensation in the central nervous system of fishes. This project explores physiological mechanisms of climate adaptation in key sentinel species and expands the sequencing resources of the polar science community by generating the first long-read genome for Arctic cod, Boreogadus saida.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
北冰洋正在以高达全球平均水平七倍的速度变暖,危及并转移了主要的谋生和商业渔业。鱼类种群受到气候变暖的压力,同时也受到海洋酸化和氧化的影响。本研究旨在描述三种北极和亚北极鱼类:北冰洋鳕鱼(Boreogadus Saida)、藏红花鳕鱼(Eleginus Gracilis)和大西洋鳕鱼(Gadus Morhua)感觉系统中整合了变暖、pH变化和氧化信号的蛋白质的演变。研究这些感觉机制的进化有助于洞察鱼类对气候变化的敏感性和反应。这项工作对理解蛋白质诱导的人类疼痛、炎症和瘙痒反应也有意义。在这项研究的过程中,两名来自科学领域代表性不足群体的本科生将通过一个暑期研究项目得到指导。将制定K-12课程计划,将该项目的见解与阿拉斯加原住民科学课程和价值观以及下一代科学标准相结合。这项工作的一个主要目标是产生高质量的基因组和转录组数据,涵盖狭温和常温北极鱼类物种,以及中枢温敏神经组织、外周温敏神经组织、非温敏神经组织和非神经体细胞组织。这些数据将使用第三代(IsoSeq)和第二代(RNAseq)测序技术的组合产生,并用于表征瞬时受体潜力(Trp)通道序列和表达模式。色氨酸通道图谱将在调节和结构进化的计算机测试中进行比较,包括使用AlphaFold2预测蛋白质结构。这些图谱将在物种、组织和低温南极鱼类之间进行比较,以研究鱼类温度感觉和对寒冷的汇聚适应的中枢和外围机制。这项工作是首次对北极物种中分子温度传感器蛋白的进化进行研究,也是第一次针对鱼类中枢神经系统的温度感觉机制进行研究。Boreogadus说,该项目探索了关键哨兵物种适应气候的生理机制,并通过为北极鳕鱼生成第一个长时间阅读的基因组来扩大极地科学界的测序资源。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
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Julia York其他文献
Pregnant Women With Gain-Framed Definition of Eating Healthy Reported Higher Behavioral Control than Loss-Framed Definitions
- DOI:
10.1016/j.jneb.2024.05.051 - 发表时间:
2024-08-01 - 期刊:
- 影响因子:
- 作者:
Erin Hudson;Madalyn Rosenthal;Julia York;Carolina Flores Villarreal;Dagny Larson;Marissa Burgermaster - 通讯作者:
Marissa Burgermaster
Julia York的其他文献
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