MRI: Track 1 Acquisition of a High-Resolution Quadrupole Time-of-Flight Mass Spectrometer with Diverse Inlet and Ionization Capabilities for Chemical Analyses

MRI：轨道 1 采购具有多种入口和电离功能的高分辨率四极杆飞行时间质谱仪，用于化学分析

• 批准号: 2319939
• 负责人: Amanda Patrick
• 金额: $ 54.07万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319939&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Resolution; Quadrupole

This award is jointly funded by the Major Research Instrumentation Program, the Chemistry Research Instrumentation Program, and the Established Program to Stimulate Competitive Research (EPSCoR). It supports the acquisition of instrumentation for ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry (UPLC-qToF) by Mississippi State University, strengthening the research instrumentation infrastructure in Mississippi. High-resolution mass spectrometry is a critical instrumental technique for the characterization of new synthetic chemical species and is a sensitive method for detecting and characterizing low-concentration species, for example in biological and environmental samples. Twelve research groups in the Department of Chemistry are identified as users and the instrument will also be available to other researchers from across campus and beyond. In addition to supporting research activities, the instrument will also be used for educational activities, including training of student researchers and incorporation into laboratory courses. The new instrument will ensure that researchers at Mississippi State University continue to have access to state-of-the-art high-resolution mass spectrometry required for the characterization of novel syntheses and reaction monitoring. Several projects will make use of this aspect of the instrument, with examples including characterization of heterobimetallic complexes for hydrodenitrogenation processes relevant to production of cleaner fuels, characterization of catalysts and reaction products aimed at performing organic transformations in sustainable solvents like water or ethanol, and characterization of catalysts and reactions aimed at improving stereo- and site-selective functionalizations and transformations relevant to pharmaceutical manufacture among other applications. The new instrument has excellent sensitivity and is coupled to an ultra-high performance chromatography instrument, allowing for analyte species to be measured in low-concentration and/or complex matrix samples. Examples of research that will benefit from these aspects of the instrument include characterization of the adsorption and decomposition of polyfluoroalkyl substances (PFAS) with modified biochar and the characterization of ionic liquid degradation products that may be relevant as emerging environmental contaminants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器计划，化学研究仪器计划和刺激竞争性研究的既定计划（EPSCoR）共同资助。它支持密西西比州立大学购置超高效液相色谱仪和高分辨率四极杆飞行时间质谱仪，加强了密西西比的研究仪器基础设施。高分辨率质谱是表征新合成化学物种的关键仪器技术，也是检测和表征生物和环境样品等低浓度物种的灵敏方法。化学系的12个研究小组被确定为用户，该仪器也将提供给校园内外的其他研究人员。除了支持研究活动外，该仪器还将用于教育活动，包括培训学生研究人员和纳入实验室课程。新仪器将确保密西西比州立大学的研究人员继续获得表征新合成和反应监测所需的最先进的高分辨率质谱仪。有几个项目将利用该文书的这一方面，其实例包括与生产清洁燃料有关的加氢脱氮工艺的杂环化合物的表征，旨在水或乙醇等可持续溶剂中进行有机转化的催化剂和反应产物的表征，和表征的催化剂和反应，旨在改善立体和网站，在其它应用中，与药物制造相关的选择性官能化和转化。新仪器具有出色的灵敏度，并与超高效色谱仪耦合，允许在低浓度和/或复杂基质样品中测量分析物。将从该仪器的这些方面受益的研究实例包括多氟烷基物质（PFAS）的吸附和分解的表征该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的评估来支持。影响审查标准。