PFI (MCA): Improving Dental Technology using Microbial Transplantation in the Mouth

PFI (MCA)：利用口腔微生物移植改进牙科技术

• 批准号: 2322229
• 负责人: Laura Weyrich
• 金额: $ 35万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2322229&HistoricalAwards=false
• 关键词: PFI; MCA; Improving; Dental; Technology

The broader impact of this Partnerships for Innovation (Mid-Career Advancement) (PFI (MCA)) project is to develop a new dental technology that has the potential to improve oral health. This project will use dental plaque collected from healthy donors and test how it may be used in oral microbiome transplantation – that is, the movement of bacteria from the mouth of a healthy donor to someone who struggles with oral issues such as dental decay (caries) or gum disease (periodontal disease). Specifically, this project will test the introduction of different mixtures of beneficial microbes into the mouth of people with different diets, lifestyles, or diseases. The development of this technology will also support the career development of a woman faculty member-entrepreneur who will build a company. She will use her experiences to educate the public and other women who are interested in building their own companies. As a result, this project builds the foundation for development of a new technology that can be commercialized for the dentist’s office or for an at-home treatment to prevent dental decay and periodontal disease. This project will develop a new technology to improve oral health. Dental decay and periodontal disease are two of the most chronic diseases experienced globally. New technologies are needed to prevent and treat oral disease, especially treatments that help develop healthy microorganisms in the mouth. This project generates basic information on how donated dental plaque – with thousands of oral microbes – can be transplanted into someone who needs them to improve health. This research will examine how successful these microbial transplantations are in people who eat different foods, live different lifestyles, or suffer from different diseases. This research employs a new 3D printed system that can grow, propagate, and compete microorganisms from dental plaque in the laboratory to examine this problem. The project will inform how to match the correct donor to the right recipient and determine which microbes are best to transplant using a reproducible system in the laboratory. The results will be used to develop and commercialize this technology for dentists and people struggling with oral disease.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个创新伙伴关系（中期职业发展）（PFI（MCA））项目的更广泛的影响是开发一种新的牙科技术，有可能改善口腔健康。该项目将使用从健康捐赠者收集的牙菌斑，并测试它如何用于口腔微生物组移植-也就是说，细菌从健康捐赠者的口腔移动到患有口腔问题的人，如蛀牙（龋齿）或牙龈疾病（牙周病）。具体来说，该项目将测试将不同的有益微生物混合物引入具有不同饮食，生活方式或疾病的人的口中。这项技术的发展还将支持一名女教师-将建立一家公司的企业家的职业发展。她将利用自己的经验教育公众和其他有兴趣建立自己公司的妇女。因此，该项目为开发一种新技术奠定了基础，该技术可用于牙科诊所或家庭治疗，以预防蛀牙和牙周病。该项目将开发一种新技术来改善口腔健康。蛀牙和牙周病是全球最常见的两种慢性疾病。需要新技术来预防和治疗口腔疾病，特别是有助于在口腔中培养健康微生物的治疗。这个项目产生了关于捐赠的牙菌斑-成千上万的口腔微生物-如何移植到需要它们来改善健康的人身上的基本信息。这项研究将研究这些微生物移植在吃不同食物、过不同生活方式或患有不同疾病的人身上的成功率。这项研究采用了一种新的3D打印系统，该系统可以在实验室中生长，繁殖和竞争牙菌斑中的微生物来研究这个问题。该项目将告知如何将正确的供体与正确的受体相匹配，并确定哪些微生物最适合在实验室中使用可重复的系统进行移植。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。