SBIR Phase I: Industrial-Scale Technology for Drug Development in Mature Human Fat Cells

SBIR 第一阶段：成熟人类脂肪细胞药物开发的工业规模技术

• 批准号: 2322443
• 负责人: Benjamin Pope
• 金额: $ 27.5万
• 依托单位: MELLICELL, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-15 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2322443&HistoricalAwards=false
• 关键词: SBIR; Phase; Industrial; Scale; Technology

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to increase the scale and throughput of novel technology with the potential to enable the discovery and development of next-generation therapeutics for obesity and the array of associated medical conditions that can be ameliorated with weight loss. This technology could also be expanded to therapeutic development to address other reproductive and ageing disorders characterized by diseased fat cells.This project may enable drug development in human fat cells at a previously unattainable quality and scale. For the last 50 years, the first stage of drug development in adipocytes has been limited by the lack of a tractable system that faithfully reproduces the clinical features of mature fat cells. The technology in this project could efficiently turn adult human stem cells into fat cells and accelerate their maturation thousands of times relative to conventional methods. Adipocytes generated by this new technology may more closely match the cellular shape and size, gene expression profile, and function of mature fat cells in adults. Scaling the technology will require development of novel devices for automation and the design and testing of customized protocols. Success will be determined by measures of manufacturing quality control and specific properties of mature human fat tissue.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

小型企业创新研究(SBIR)第一阶段项目的更广泛影响是增加新技术的规模和产量，有可能发现和开发下一代肥胖疗法以及一系列可以通过减肥改善的相关医疗条件。这项技术还可以扩展到治疗开发，以解决以脂肪细胞病变为特征的其他生殖和衰老障碍。该项目可能使人类脂肪细胞的药物开发达到以前无法达到的质量和规模。在过去的50年里，脂肪细胞药物开发的第一阶段一直受到限制，因为缺乏一个可忠实地再现成熟脂肪细胞临床特征的易处理系统。该项目中的技术可以有效地将成人干细胞转化为脂肪细胞，并比传统方法加速数千倍的成熟。通过这项新技术产生的脂肪细胞可能更接近成人成熟脂肪细胞的细胞形状和大小、基因表达谱和功能。推广这项技术将需要开发用于自动化的新设备，以及设计和测试定制的协议。成功与否将取决于制造质量控制措施和成熟人类脂肪组织的特定性质。该奖项反映了NSF的法定使命，并已通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。