Carbazo-anilines: Enantioselective cross-dehydrogenative amination reactions for the preparation of unsymmetrical chiral diamines molecules, and their applications as enantiopure ligands

碳偶氮苯胺：这项提议的总体目标是研究获得轴向手性对映体邻位碳偶氮苯胺的不同途径，并评估这些化合物作为手性配体的潜力。主要目的是设计一种对映体选择性方法，以便直接获得富含对映体的C-N交叉偶联产物。这项技术将从我们最近交流的最初的外消旋方法中衍生出来，通过C-N键形成交叉脱氢偶联。这个项目是创新的，因为我们在这里研究了一种史无前例的轴向手性，令人惊讶的是，它不是基于立体结构，而是基于独特的分子内NH-N H键。

Carbazo-anilines: The general objective of this proposal is to investigate different pathways to access axially chiral enantiopure ortho-carbazo-anilines and to evaluate the potential of these compounds as chiral ligands. The main objective is to devise an enantioselective method in order to directly access enantio-enriched C-N cross-coupled products. This technology would be derived from the original racemic method that we have recently communicated, through C-N bond forming Cross-Dehydrogentive-Coupling. This project is innovative because we study here an unprecedented type of axial chirality, which is surprisingly not based on sterics, but on a unique intra-molecular NH-N H-bond.