Carbazo-anilines: Enantioselective cross-dehydrogenative amination reactions for the preparation of unsymmetrical chiral diamines molecules, and their applications as enantiopure ligands

卡偶氮苯胺：用于制备不对称手性二胺分子的对映选择性交叉脱氢胺化反应及其作为对映纯配体的应用

• 批准号: 257130133
• 负责人: Professor Dr. Frederic W. Patureau
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/257130133?language=en
• 关键词: Carbazo; anilines; Enantioselective; cross; dehydrogenative

Carbazo-anilines: The general objective of this proposal is to investigate different pathways to access axially chiral enantiopure ortho-carbazo-anilines and to evaluate the potential of these compounds as chiral ligands. The main objective is to devise an enantioselective method in order to directly access enantio-enriched C-N cross-coupled products. This technology would be derived from the original racemic method that we have recently communicated, through C-N bond forming Cross-Dehydrogentive-Coupling. This project is innovative because we study here an unprecedented type of axial chirality, which is surprisingly not based on sterics, but on a unique intra-molecular NH-N H-bond.

氨基甲酰苯胺：本提案的总体目标是研究不同的途径，以获得轴向手性对映体纯邻咔唑苯胺，并评估这些化合物作为手性配体的潜力。主要目的是设计一种对映体选择性的方法，以直接获得对映体富集的C-N交叉偶联产物。该技术将源自我们最近交流的原始外消旋方法，通过C-N键形成交叉脱氢偶联。这个项目是创新的，因为我们在这里研究了一种前所未有的轴向手性，这是令人惊讶的不是基于立体，但在一个独特的分子内NH-N氢键。