Conference: 2023 Mammalian Synthetic Biology Workshop

哺乳动物合成生物学是设计遗传装置，使研究和控制哺乳动物细胞中的生物过程提供工具和设计策略，以加速各种疗法的进步；因此，从长远来看，许多正在开发的技术将对最终的医疗用途有用。2023年国际哺乳动物合成生物学研讨会（mSBW）将汇集合成生物学的领导者和其他相关领域的专家，以突出和启发尖端的合成生物学和细胞研究。该项目以基础技术、记录仪、电路和动力学、再生医学和类器官以及免疫工程为特色，鼓励学生参与，以培养新一代工程师。这项研究通过帮助我们更好地了解和诊断疾病，更快地发现有效的治疗方法和为个人开发精准医学，对社会产生积极影响。通过关注哺乳动物合成生物学的广泛应用，会议创造了一个独特的环境，聚集了具有不同专业知识、技能和经验水平的研究人员。这使得很少有机会互动的人们能够交流思想、知识和合作机会。会议的资金还将支持工程界代表性不足的群体出席会议。研讨会将强调新的计算工具/方法，以帮助预测和定量研究系统行为。从长远来看，基础科学、工程技术和计算模型的进步将对医药产品的发展至关重要，因为它将有助于提高对疾病的理解、监测和治疗。研讨会将包括五个技术会议：(1)基础进展，(2)干细胞应用，(3)免疫治疗和细胞治疗，(4)基因调控，(5)传感器和多输入逻辑。研讨会还将举办几次问答讨论、交流休息以及海报环节，让学生展示他们的作品。我们希望各种交流机会将使与会者有能力讨论所展示的最先进的技术，并且讨论将导致可能加速该领域发展的潜在合作。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Mammalian synthetic biology is the design of genetic devices that enables the study and control of biological processes in mammalian cells to provide the tools and design strategies to accelerate the advancement of various therapies; therefore, many of the technologies being developed will be useful for eventual medical use in the long term. The 2023 International Mammalian Synthetic Biology Workshop (mSBW) will bring together leaders in synthetic biology with experts from other relevant fields to highlight and inspire cutting-edge synthetic biology and cellular research. The program features talks on foundational technologies, reporters and recorders, circuits and dynamics, regenerative medicine and organoids, and immunoengineering that encourages the participation of students in order to train a new generation of engineers. This research positively impacts society by helping us to better understand and diagnose diseases, more rapidly discover effective therapeutics and develop precision medicine for individuals. By focusing on mammalian synthetic biology across a broad range of applications, the meeting creates a unique environment to gather researchers with varying expertise, skillsets and levels of experience. This allows for the exchange of ideas, knowledge and opportunities for collaboration between people who rarely have the opportunity to interact. Funding for the conference will also support the attendance of underrepresented groups in engineering. The workshop will emphasize novel computational tools/methods to aid in predicting and quantitatively studying system behavior. The advances in fundamental science, engineering techniques, and computation models will be critical for the development of medicinal products in the long term as it will be useful for improving understanding, monitoring, and treatment of disease. The workshop will contain five technical sessions: (1) Foundational advances, (2) Applications in stem cells, (3) Immunotherapy and cell therapy, (4) Gene regulation, (5) Sensors and multi-input logic. The workshop will also host several Q&A discussions, networking breaks, as well as poster sessions that allow students to present their work. It is our hope that the various networking opportunities will give the attendees the ability to discuss the state-of-the-art technology being presented, and that the discussions will lead to potential collaborations that may accelerate development in the field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.