I-Corps: Mini-Disc Point-of-Care Personalized Diagnostic Platform

I-Corps项目的更广泛的影响/商业潜力是用于医疗保健应用的便携式单细胞电动分离平台。它可以在医院、医疗办公室和实验室实施，通过允许广泛的样本到答案的生物测试来改善患者的治疗效果。这被认为是一种个性化的诊断，可以在医生办公室和病人床边进行，包括循环肿瘤细胞的早期诊断或败血症或心脏病发作的测试，也可以用于改进生物制药药物的发现和生物合成。这个I-Corps项目是基于电动微纳米组装工艺的发展。概述技术开发和商业化项目的目标是创建一个通用的便携式离心微流控平台，该平台将适用于从一般流体化学分析到生物标志物分析和单细胞分析的广泛测试。这个平台可以在医院和医疗办公室以及科学实验室中广泛使用。提出的紧凑型微流控系统将样品预处理能力统一在离心微流控平台上，与生物细胞和分子的电动分选、分离和捕获相结合。提议的团队有专业知识、能力和所需的资源来承担所提议的离心微流体样品到答案平台的技术开发和商业化。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is a portable single cell electrokinetic separation platform for healtchare applications. It can be implemented in hospitals, medical offices, and laboratories to improve patient outcomes by allowing for a wide array of sample-to-answer biological tests. This is considered a personalized diagnostic and can be performed in doctors’ offices and at the patient bedside, including early diagnostic of circulating tumor cells or testing for sepsis or heart attack, and also for improving biopharmaceutical drug discovery and biosynthesis. This I-Corps project is based on the development of the electrokinetic micro- and nano-assembly process. The goal of the outlined technology development and commercialization project is to create a universal portable centrifugal microfluidic platform that will be applicable for a wide range of tests from general fluid chemistry assays to biomarker assays and single cell analysis. This platform could find widespread use in hospitals and medical offices as well as in scientific laboratories. The proposed compact microfluidic system unifies sample preprocessing capabilities possible on a centrifugal microfluidic platform with electrokinetic sorting, separation, and capture of biological cells and molecules. The proposing team has expertise, capability, and needed resources to undertake the technical development and commercialization of the proposed centrifugal microfluidic sample-to-answer platform.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.