Planning: HBCU-UP: OPEN: Collaborative STEM Education, Research, and Workforce Development in Biomanufacturing Through Biotechnology and Bioinformatics Training

规划：HBCU-UP：开放：通过生物技术和生物信息学培训在生物制造领域开展协作 STEM 教育、研究和劳动力发展

• 批准号: 2332512
• 负责人: Tyrell Carr
• 金额: $ 20万
• 依托单位: Saint Augustine's College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2332512&HistoricalAwards=false
• 关键词: Planning; HBCU; UP; OPEN; Collaborative

The Historically Black Colleges and Universities - Undergraduate Program (HBCU-UP) provides support to strengthen STEM undergraduate education and research at HBCUs. This project will coordinate planning activities for Saint Augustine’s University (SAU) to reimagine STEM by focusing on its proximity to Research Triangle Park, NC and the growing industry in biomanufacturing. The planning work outlines a strategy for developing new, innovative, and transformative partnerships with neighboring universities and industry affiliates and integrating biotechnology and bioinformatics training to prepare SAU students for the biomanufacturing workforce and/or entry into STEM graduate programs. This partnership effort will provide faculty internship opportunities in biotechnology and bioinformatics at a major research university and a bridge to biomanufacturing sciences training program for students at SAU. This strategy also involves the integration of biotechnology and bioinformatics content and skill acquisition into laboratory courses at SAU.The goals of this project are to (1) integrate biotechnology and bioinformatics training in the genetics laboratory course and molecular cell biology laboratory course for biomanufacturing workforce development, (2) provide STEM majors with a biomanufacturing sciences training experience through a summer program, and (3) support advanced training in biotechnology or bioinformatics for STEM faculty. Within the genetics laboratory course, STEM majors will be exposed to hands-on training centered on CRISPR/Cas9 genome editing and high-throughput DNA sequencing to genetically engineer an organism and characterize an organism at the molecular level, respectively. Within the molecular cell biology laboratory course, STEM majors will be exposed to hands-on training in high-throughput selection to identify and recover a protein of interest and characterize protein interactions. The summer biomanufacturing sciences training program will provide STEM majors industry-based technical and research skills training in protein expression, recovery, characterization, and bioactivity. STEM faculty supported to receive advanced training in biotechnology or bioinformatics will be expected to integrate training in laboratory courses and research. The project will also support expert facilitators to provide students with advanced training in biotechnology, bioinformatics, and biomanufacturing. Overall, the working hypothesis of this project is the integration of biotechnology and bioinformatics in laboratory courses and summer training will lead to students accomplishing the following goals: project ownership, self-efficacy, mastery of techniques, overcoming challenges in research, increased communication skills, and feeling a connection to a larger scientific community. For evaluation purposes, aspects of these goals will be assessed through structured anonymous feedback mechanisms. A potential contribution to science is preparing competitive STEM majors for the biomanufacturing workforce or entering fields of study that support biomanufacturing sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

历史上的黑人学院和大学-本科生计划（HBCU-UP）为加强HBCUs的STEM本科教育和研究提供支持。该项目将协调圣奥古斯丁大学（SAU）的规划活动，通过专注于其靠近北卡罗来纳州研究三角公园和不断增长的生物制造业来重新构想STEM。规划工作概述了与邻近大学和行业分支机构建立新的，创新的和变革性的合作伙伴关系的战略，并整合生物技术和生物信息学培训，为SAU学生的生物制造劳动力和/或进入STEM研究生课程做好准备。这种合作关系的努力将提供教师在生物技术和生物信息学在一个主要的研究型大学实习的机会，并在SAU的学生生物制造科学培训计划的桥梁。该项目的目标是（1）将生物技术和生物信息学培训整合到遗传学实验室课程和分子细胞生物学实验室课程中，以促进生物制造劳动力的发展，（2）通过暑期课程为STEM专业提供生物制造科学培训经验，以及（3）支持STEM教师在生物技术或生物信息学方面的高级培训。在遗传学实验室课程中，STEM专业的学生将接受以CRISPR/Cas9基因组编辑和高通量DNA测序为中心的实践培训，以分别在分子水平上对生物体进行遗传工程改造和表征。在分子细胞生物学实验室课程中，STEM专业的学生将接受高通量选择的实践培训，以识别和恢复感兴趣的蛋白质并表征蛋白质相互作用。夏季生物制造科学培训计划将为STEM专业提供蛋白质表达，恢复，表征和生物活性方面的基于行业的技术和研究技能培训。支持接受生物技术或生物信息学高级培训的STEM教师将有望整合实验室课程和研究的培训。该项目还将支持专家主持人为学生提供生物技术，生物信息学和生物制造方面的高级培训。总体而言，该项目的工作假设是将生物技术和生物信息学整合到实验室课程中，暑期培训将使学生实现以下目标：项目所有权，自我效能，掌握技术，克服研究中的挑战，提高沟通技巧，并感受到与更大的科学界的联系。为了评价的目的，将通过结构化的匿名反馈机制对这些目标的各个方面进行评估。对科学的潜在贡献是为生物制造劳动力准备有竞争力的STEM专业或进入支持生物制造科学的研究领域。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。