Investigation of cortico-subcortical dynamics in sensorimotor integration (A09)

感觉运动整合中皮质-皮质下动力学的研究（A09）

• 批准号: 258570330
• 金额: --
• 依托单位: Abteilung für Systemische Neurowissenschaften
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/258570330?language=en
• 关键词: Investigation; cortico; subcortical; dynamics; sensorimotor

When tactile information reaches the somatosensory cortex, it is not only communicated to other cortical areas, but the cortex also projects back to sub-cortical areas to regulate the information flow, depending on the behavioural context. In this project we investigate the activity in cortical cells that project back to the thalamus, where they can modulate thalamic activity. This feedback modulation is directed at first-order and higher order thalamic nuclei, that work in parallel to process information. Broadly speaking, activity in the corticothalamic cells may serve to strengthen either detection or discriminability. Activity in the corticothalamic cells affect sensory adaptation in both cortex and thalamus, and this is one mechanism by which information processing can be optimised. In this project we use optogenetics to control the activity in different populations of corticothalamic cells, and in combination with in vivo electrophysiology, we use this method to investigate how the thalamo-cortico-cortical circuit is regulated depending on behavioural context.

当触觉信息到达躯体感觉皮层时，它不仅被传递到其他皮层区域，而且皮层还投射回皮层下区域以调节信息流，这取决于行为背景。在这个项目中，我们研究了投射回丘脑的皮质细胞的活动，在那里它们可以调节丘脑的活动。这种反馈调制针对一阶和高阶丘脑核，它们并行工作以处理信息。从广义上讲，皮质丘脑细胞的活动可能有助于加强检测或区分能力。皮质丘脑细胞的活动会影响皮质和丘脑的感觉适应，这是优化信息处理的一种机制。在这个项目中，我们使用光遗传学来控制不同群体的皮质丘脑细胞的活性，并结合体内电生理学，我们使用这种方法来研究丘脑-皮质-皮质回路如何根据行为环境进行调节。