TRPC cation channels in hypoglycemia-associated autonomic nervous system failure in diabetes models (B02)

糖尿病模型中低血糖相关自主神经系统衰竭中的 TRPC 阳离子通道 (B02)

• 批准号: 259831326
• 金额: --
• 依托单位: Pharmakologisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259831326?language=en
• 关键词: TRPC; cation; channels; hypoglycemia; associated

In B02 we aim to identify relevant neurons and neuroendocrine cells in the brain stem and adrenal medulla, respectively, that rely on TRPC channels during sympatho-adrenal counter-regulation to hypoglycemia. TRPC channel functions and their impact for cellular Ca2+ homeostasis and Ca2+ dependent exocytosis of catecholamines will be analysed. Based on hitherto and further metabolome studies the project aims to develop new interventional therapeutic approaches for „Hypoglycemia-associated autonomic failure“.

在B 02中，我们的目标是分别鉴定脑干和肾上腺髓质中的相关神经元和神经内分泌细胞，它们在交感-肾上腺对低血糖的反调节过程中依赖于TRPC通道。将分析TRPC通道功能及其对细胞Ca 2+稳态和Ca 2+依赖的儿茶酚胺胞吐作用的影响。基于迄今为止和进一步的代谢组学研究，该项目旨在为“低血糖相关自主神经功能衰竭”开发新的介入治疗方法。