TRPC cation channels in hypoglycemia-associated autonomic nervous system failure in diabetes models (B02)

在B02中，我们的目标是识别脑干和肾上腺髓质中依赖TRPC通道的相关神经元和神经内分泌细胞，这些细胞在交感-肾上腺对低血糖的反向调节过程中。TRPC通道的功能及其对细胞内钙稳态和儿茶酚胺的钙依赖性胞吐的影响将被分析。基于迄今和进一步的代谢组研究，该项目旨在开发新的介入治疗方法，治疗“低血糖相关的自主神经衰竭”。

In B02 we aim to identify relevant neurons and neuroendocrine cells in the brain stem and adrenal medulla, respectively, that rely on TRPC channels during sympatho-adrenal counter-regulation to hypoglycemia. TRPC channel functions and their impact for cellular Ca2+ homeostasis and Ca2+ dependent exocytosis of catecholamines will be analysed. Based on hitherto and further metabolome studies the project aims to develop new interventional therapeutic approaches for „Hypoglycemia-associated autonomic failure“.