Reactive metabolites in the progression of the diabetic tubulopathy and its association to mitochondrial dysfunction und lipid droplets (C04)

在糖尿病肾病中，肾功能与肾小管间质损伤程度的关系大于与肾小球损伤程度的关系。线粒体功能障碍和脂滴积聚是糖尿病小管上皮的特征。本项目采用体外和体内研究方法，研究在应激性代谢物增加的条件下LDs的生物发生/结构机制及其对线粒体功能的影响。此外，线粒体功能与肾素血管紧张素系统和脂质配体控制的核受体的相互作用将在糖尿病肾病的背景下进行研究。

In diabetic nephropathy the renal function correlates more with the degree of tubulointerstitial injury than that of the glomerular lesions. The mitochondrial dysfunction and the accumulation of lipid droplets (LDs) are characteristic features of the diabetic tubulus epithel. Using vitro und in vivo approaches, this project addresses the mechanisms of biogenesis/structure of LDs and their effect on the mitochondrial function under conditions of increased stress by reactive metabolites. Moreover, the interaction of the mitochondrial function with the renin angiotensin system and with lipid ligand controlled nuclear receptors will be studied in the context of diabetic nephropathy.