Reactive metabolites in the progression of the diabetic tubulopathy and its association to mitochondrial dysfunction und lipid droplets (C04)

糖尿病肾小管病进展中的反应性代谢物及其与线粒体功能障碍和脂滴的关系 (C04)

• 批准号: 259917553
• 金额: --
• 依托单位: Zentrum für Medizinische Forschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259917553?language=en
• 关键词: Reactive; metabolites; progression; diabetic; tubulopathy

In diabetic nephropathy the renal function correlates more with the degree of tubulointerstitial injury than that of the glomerular lesions. The mitochondrial dysfunction and the accumulation of lipid droplets (LDs) are characteristic features of the diabetic tubulus epithel. Using vitro und in vivo approaches, this project addresses the mechanisms of biogenesis/structure of LDs and their effect on the mitochondrial function under conditions of increased stress by reactive metabolites. Moreover, the interaction of the mitochondrial function with the renin angiotensin system and with lipid ligand controlled nuclear receptors will be studied in the context of diabetic nephropathy.

在糖尿病肾病中，肾功能与肾小管间质损伤程度的相关性高于与肾小球病变的相关性。线粒体功能障碍和脂滴（LD）的积累是糖尿病肾小管上皮的特征。该项目采用体外和体内方法，研究 LD 的生物发生/结构机制及其在反应性代谢物应激增加的条件下对线粒体功能的影响。此外，将在糖尿病肾病的背景下研究线粒体功能与肾素血管紧张素系统和脂质配体控制的核受体的相互作用。