Role of proteolysis in interleukin-11 signaling (A10)

蛋白水解在 IL-11 信号传导 (A10) 中的作用

• 批准号: 259995327
• 金额: --
• 依托单位: Institut für Klinische Biochemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259995327?language=en
• 关键词: Role; proteolysis; interleukin; 11; signaling

The project deals with IL-11, which can activate cells through an ADAM10-cleaved fragment of the membrane bound IL-11 receptor, a process that has been termed IL-11 trans-signaling. The regulation of IL-11R proteolysis by ADAM10, the cleavage of the IL-11R by rhomboid and other proteases and the functional role of IL-11 classic and trans-signaling will be analyzed. The role of IL-11 in colon cancer will be addressed and novel inhibitors of ADAM10 will be developed that will allow to block ADAM10-mediated IL-11R cleavage in a cell specific manner.

该项目涉及IL-11，它可以通过adam10切割的膜结合IL-11受体片段激活细胞，这一过程被称为IL-11反式信号传导。我们将分析ADAM10对IL-11R蛋白水解的调控，菱形等蛋白酶对IL-11R的切割，以及IL-11经典信号和反式信号的功能作用。IL-11在结肠癌中的作用将得到解决，ADAM10的新型抑制剂将被开发出来，以细胞特异性的方式阻断ADAM10介导的IL-11R切割。