SFB 1181: Checkpoints for Resolution of Inflammation

炎症是人体最重要的防御策略。当不再需要时，炎症需要被解决。炎症分解受损会导致慢性疾病，如关节炎、结肠炎和哮喘。CRC1181旨在定义炎症消退的机制，并确定支持消退过程的途径以及那些克服消退并导致炎症慢性化的途径。在过去的两个资助期中，我们定义了控制组织特定炎症消退的关键节点。此外，还开发了新的方法来研究体内炎症的动力学。此外，治疗方法已被发现可促进免疫介导性炎症性疾病的解决。在第三个资助期，我们将利用(I)炎症消退期间免疫新陈代谢方面的新见解，(Ii)允许炎症重置的治疗方法，以及(Iii)在炎症期间提供前所未有的组织变化视角的技术。为了实现这些目标，CRC1181对其科学家团队进行了重大重组，并整合了新技术。这一战略将推动创新，并在第三个资助期内遏制人类疾病炎症的机制和治疗方法方面产生新的见解。

Inflammation is the most important defense strategy of the body. Inflammation needs to be resolved, when no longer needed. Impaired resolution of inflammation leads to chronic diseases like arthritis, colitis and asthma. CRC1181 aims to define the mechanism of resolution of inflammation and to identify pathways that support the resolution process as well as those that overcome resolution and lead to chronicity of inflammation. In the last two funding periods we have defined critical nodes that control tissue specific resolution of inflammation. Furthermore, new methods have been developed that allow to study the dynamics of inflammation in vivo. In addition, therapeutic approaches have been discovered that foster resolution of immune-mediated inflammatory diseases. In the third funding period, we will leverage on (i) new insights in the immune metabolism during resolution of inflammation, (ii) therapeutic approaches to allow reset of inflammation and (iii) technologies that provide an unprecedented view in tissue changes during inflammation. To accomplish these goals CRC1181 has substantially restructured its team of scientists and has integrated new technologies. This strategy will push innovation and create new insights in the mechanisms and therapeutic approaches to stop inflammation in human disease during the third funding period.