SFB 1181: Checkpoints for Resolution of Inflammation

炎症是身体最重要的防御策略。炎症需要解决，当不再需要的时候。炎症消退受损会导致关节炎、结肠炎和哮喘等慢性疾病。CRC1181旨在确定炎症消退的机制，并确定支持消退过程的途径以及克服消退并导致炎症慢性的途径。在过去的两个资助期，我们已经定义了控制组织特异性炎症解决的关键节点。此外，已经开发出新的方法来研究体内炎症的动力学。此外，治疗方法已被发现，促进解决免疫介导的炎症性疾病。在第三个资助期，我们将利用(i)在炎症消退期间免疫代谢的新见解，（ii）允许炎症重置的治疗方法，以及（iii）在炎症期间组织变化方面提供前所未有的技术。为了实现这些目标，CRC1181大幅重组了其科学家团队，并整合了新技术。这一战略将在第三个资助期内推动创新，并在机制和治疗方法方面创造新的见解，以阻止人类疾病中的炎症。

Inflammation is the most important defense strategy of the body. Inflammation needs to be resolved, when no longer needed. Impaired resolution of inflammation leads to chronic diseases like arthritis, colitis and asthma. CRC1181 aims to define the mechanism of resolution of inflammation and to identify pathways that support the resolution process as well as those that overcome resolution and lead to chronicity of inflammation. In the last two funding periods we have defined critical nodes that control tissue specific resolution of inflammation. Furthermore, new methods have been developed that allow to study the dynamics of inflammation in vivo. In addition, therapeutic approaches have been discovered that foster resolution of immune-mediated inflammatory diseases. In the third funding period, we will leverage on (i) new insights in the immune metabolism during resolution of inflammation, (ii) therapeutic approaches to allow reset of inflammation and (iii) technologies that provide an unprecedented view in tissue changes during inflammation. To accomplish these goals CRC1181 has substantially restructured its team of scientists and has integrated new technologies. This strategy will push innovation and create new insights in the mechanisms and therapeutic approaches to stop inflammation in human disease during the third funding period.