The role of NEPH-NEPHRIN proteins as regulators of neuron and kidney morphogenesis (A02)

NEPH-NEPHRIN 蛋白作为神经元和肾脏形态发生调节剂的作用 (A02)

• 批准号: 267103346
• 金额: --
• 依托单位: Klinik für Innere Medizin IV - Nephrologie und Allgemeinmedizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267103346?language=en
• 关键词: role; NEPH; NEPHRIN; proteins; regulators

The slit diaphragm of the podocytes is mainly constituted by the cell-cell adhesion module NEPH-NEPHRIN and a prerequisite for blood filtering. The cell-cell adhesion module NEPH-NEPHRIN was conserved during evolution and members of the NEPH-NEPHRIN protein family are involved in the synapse development and the synaptic target recognition. Aim of this study is the identification and characterization of molecular processes interlinking the NEPH-NEPHRIN adhesion module with intracellular signaling pathways and the actin cytoskeleton. C. elegans as a model system provides a unique opportunity to investigate protein functions directly in vivo and to decode signaling cascades.

足细胞的狭缝隔膜主要由细胞-细胞粘附模块NEPH-NEPHRIN构成，是血液过滤的先决条件。细胞-细胞粘附模块NEPH-NEPHRIN在进化过程中是保守的，并且NEPH-NEPHRIN蛋白家族的成员参与突触发育和突触靶点识别。本研究的目的是鉴定和表征NEPH-NEPHRIN粘附模块与细胞内信号传导途径和肌动蛋白细胞骨架相互联系的分子过程。C.线虫作为模型系统提供了一个独特的机会，直接在体内研究蛋白质的功能和解码信号级联。