Genetische Risikovarianten für chronische Nierenerkrankungen in einer prospektiven Studie von 5.217 Patienten (A05)
Genetische Risikovarianten für chronische Nierenerkrankungen in einer prospektiven Studie von 5.217 Patienten (A05)
一项对 5,217 名患者进行的前瞻性研究中慢性肾病的遗传风险变异 (A05)
批准号：
267108699
负责人：
金额：
$0.0万
依托单位国家：
德国
项目类别：
Collaborative Research Centres
财政年份：
2015
资助国家：
德国
项目状态：
已结题
起止时间：
2014-12-31 至 2018-12-31
中文摘要
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英文摘要
In this project we will examine the genetic disposition to membranous nephropathy (MN) and focal-segmental glomerulosclerosis (FSGS) as model diseases for chronic kidney disease (CKD). Genetic risk variants for MN, FSGS and all-cause CKD will be mapped using genome-wide association studies with >10 million common SNPs and 250,000 rare disruptive variants in a large prospective study of 5,217 CKD patients. Validated risk variants will be investigated for interactions, their relation to different CKD etiologies, and their effect on the CKD progression and complications. This project will contribute novel insights into the genetic architecture of all-cause CKD and specifically into its glomerular components.
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