Monitoring behaviorally relevant spatio-temporal activity patterns in prefrontal networks using in vivo wide field-microendoscopy (B04)

对预期的回报做出反应是一个基本的心理过程。它的损害可能导致冲动和强迫行为，这两个特征在包括成瘾在内的许多精神病理学中都是关键特征。当动物面临不同的奖励选择时，内侧前额叶皮质(MPFC)中稀疏分布的神经元群(集合)被激活。利用分子活性标记和来自mPFC亚区的纵向体内钙成像记录，我们希望深入了解参与选择自然或药物奖励的前额叶集合的形成、特异性、区分性和可塑性。

Responding to predicted rewards is a basic mental process. Its impairment may result in impulsive and compulsive actions, both key features in many psychopathologies including addictions. When an animal is faced with alternative reward options sparsely distributed populations of neurons (ensembles) are activated in the medial prefrontal cortex (mPFC). Using molecular activity tagging and longitudinal in-vivo calcium imaging recording from mPFC subregions, we want to gain insight into the formation, specificity, distinction and plasticity of prefrontal ensembles involved in the choice for natural or drug rewards.