Monitoring behaviorally relevant spatio-temporal activity patterns in prefrontal networks using in vivo wide field-microendoscopy (B04)

使用体内广域显微内窥镜监测前额叶网络中行为相关的时空活动模式（B04）

• 批准号: 267468522
• 金额: --
• 依托单位: Zentralinstitut für Seelische Gesundheit (ZI)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267468522?language=en
• 关键词: Monitoring; behaviorally; relevant; spatio; temporal

Responding to predicted rewards is a basic mental process. Its impairment may result in impulsive and compulsive actions, both key features in many psychopathologies including addictions. When an animal is faced with alternative reward options sparsely distributed populations of neurons (ensembles) are activated in the medial prefrontal cortex (mPFC). Using molecular activity tagging and longitudinal in-vivo calcium imaging recording from mPFC subregions, we want to gain insight into the formation, specificity, distinction and plasticity of prefrontal ensembles involved in the choice for natural or drug rewards.

对预期奖励的反应是一个基本的心理过程。它的损伤可能导致冲动和强迫行为，这两个关键特征在许多精神病理学，包括成瘾。当动物面临其他奖励选择时，内侧前额叶皮层（mPFC）中稀疏分布的神经元（集合）被激活。使用分子活性标记和纵向在体钙成像记录从mPFC子区域，我们要深入了解的形成，特异性，区别和可塑性的前额叶合奏参与选择自然或药物的奖励。