Robot-assisted proprioceptive and motor training in patients with Parkinson's Disease.

帕金森病(PD)是一种进行性神经退行性疾病，影响基底节和脑干。帕金森病患者上肢和下肢均有感觉和运动障碍，其主要基础是躯体感觉信息的加工和整合方面的缺陷。然而，治疗性干预的证据主要集中在行走功能、平衡和活动能力或跌倒，而缺乏针对上肢，特别是手腕的本体感觉和运动功能的干预证据。本研究正是针对这几个方面展开的。使用治疗装置腕式机器人治疗和评估腕部的本体感觉和运动功能，将收集运动学参数。腕式机器人是一种基于控制器的机器人驱动设备，具有与虚拟现实环境集成的扭矩控制系统，以便在完成到达任务的同时向用户提供视觉反馈。除了本体感觉和运动功能的改善外，可以预期的是对手写成绩的普遍影响。本研究的目的是探讨腕式机器人治疗帕金森病患者的疗效：1)腕关节本体感觉功能，2)腕关节运动功能，3)患者书写能力。

Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting the basal ganglia and the brain stem. Patients with PD suffer from sensory and motor impairments of both, upper and lower extremities, which are mainly based on deficits in the processing and integration of somatosensory information. Evidence for therapeutic interventions, however, mainly focuses on walking function, balance and mobility or falls, while there is lack of evidence for interventions addressing the proprioception and motor function of the upper extremities, specifically of the wrist. The present study is aiming on these aspects. Using the therapeutic device wristbot for treatment and assessment of proprioception and motor function of the wrist, kinematic parameters will be collected. The wristbot is a controller-based robot-driven device with a torque control system that is integrated with a virtual reality environment in order to provide a visual feedback to the user while completing reaching tasks. In addition to the improvements in proprioception and motor function, a generalisation effect on hand writing performance is to be expected. The aim of this study is to investigate the effectiveness of the wristbot therapy in PD patients to enhance 1) the proprioceptive function of the wrist, 2) the motor function of the wrist, and 3) the patients writing performance.