Functional relevance of the Rho signaling inhibitor Myosin 9B and downstream cytoskeletal proteins for cutaneous dendritic cell populations (B01)

Rho 信号抑制剂肌球蛋白 9B 和下游细胞骨架蛋白与皮肤树突细胞群的功能相关性 (B01)

• 批准号: 273666434
• 金额: --
• 依托单位: Hautklinik Mainz
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273666434?language=en
• 关键词: Functional; relevance; Rho; signaling; inhibitor

This project investigates the relevance of cytoskeletal components for cutaneous DC functions. In particular, the functional roles of the evolutionarily conserved leukocyte-specific motor protein Myo9B and the downstream cytoskeletal effector molecules Cofilin (governs F-actin turnover) and Fascin-1 (bundles F-actin, specifically expressed in DC) will be elucidated by using genetically modified DC. The course of distinct cutaneous disease models (leishmaniasis, psoriasis, hapten- and protein-specific contact dermatitis and tolerance induction) will be assessed using mice deficient for Fascin-1 or for Myo9B in DC.

本项目研究细胞骨架成分与皮肤DC功能的相关性。特别是，进化上保守的白细胞特异性运动蛋白Myo9B和下游细胞骨架效应分子Cofilin（控制f -肌动蛋白周转）和Fascin-1（在DC中特异性表达的f -肌动蛋白束）的功能作用将通过转基因DC来阐明。不同皮肤病模型（利什曼病、牛皮癣、半抗原和蛋白特异性接触性皮炎和耐受性诱导）的病程将使用DC中缺乏fasin -1或Myo9B的小鼠进行评估。