Impact of noncanonical NF-κB signaling during hapten-induced skin inflammation (C03)

我们的研究表明，非典型NF-κB信号对于适应性免疫至关重要，因为缺乏NF-κB2信号的小鼠无法发生进行性慢性接触性超敏反应。因此，我们的目标是揭示非典型NF- kb信号如何调节急性和慢性T细胞驱动的炎症过程，通过(i)在体内使用细胞类型特异性条件NF-κ b2 -/-和NIKaly/aly小鼠识别必要的细胞参与者，（ii）研究细胞在体外激活、分化和存活中的特异性损伤。（iii）分析体内T细胞活化和白细胞归巢模式的差异；（iv）揭示体外和体内特异性NF-κB2抑制的效果。

Our studies revealed that noncanonical NF-κB signaling is essential for adaptive immunity as mice deficient in NF-κB2 signaling were unable to develop progressive chronic contact hypersensitivity reactions. Thus, we aim to uncover how noncanonical NF-kB signaling modulates acute and chronic T cell driven inflammatory processes by (i) identifying the essential cellular players employing cell-type specific conditional NF-κB2-/- and NIKaly/aly mice in vivo, (ii) investigating cell specific impairments in activation, differentiation and survival in vitro, (iii) analyzing differences in T cell activation and leukocyte homing patterns in vivo and (iv) uncovering the efficacy of specific NF-κB2 inhibition in vitro and in vivo.